乳腺癌的遗传药理学研究进展:内分泌治疗与化疗

摘要/Abstract

摘要： 随着人类基因组计划的完善以及高通量基因检测技术的发展,遗传药理学研究也实现了质的飞跃,寻找到了更多可利用的研究方法和思路并将其成果应用于临床。遗传药理学旨在通过研究与人类药物代谢、排泄等相关的候选基因的变异,探讨基因多态性与药物疗效不良反应的个体、种族差异之间的关系。乳腺癌发病率在全球有逐年上升的趋势,激素治疗和化疗是乳腺癌必不可少的治疗手段,CYP2D6和ABCB1等基因的多态性已被证实与抗乳腺癌药他莫昔芬、蒽环类药物临床疗效以及毒副反应有密切关系。抗乳腺癌常用药物他莫昔芬、紫杉醇、吉西他滨及阿霉素的临床治疗反应差异及其相关基因的遗传药理学机制研究为指导乳腺癌患者个体化用药提供了许多重要的理论依据。本文综述了他莫昔芬等抗乳腺癌药物的遗传药理学研究现状及其进展。

关键词: 乳腺癌, 个体化, CYP2D6, 他莫昔芬

Abstract: Pharmacogenetics studies have rapidly developed with the completion of the Human Genome Project and rapid progress of high throughput genetic testing technology. More and more research achievements in pharmacogenetics have found its way in clinical application. Pharmacogenetics aims to find the association between genetic variability and drug efficacy and adverse effects then finally provide theoretical foundation for tailored therapy. Breast cancer is a global health problem and its incidence has been increasing in recent years. CYP2D6 has proved to be one of pharmacogenetics factors of influencing the anti-breast cancer drug tamoxifen. This article reviews the variance of genetic factors that contribute to the individual difference of anti-breast cancer drugs response.

Key words: Breast cancer, Tailored Therapy, CYP2D6, Tamoxifen

中图分类号:

R968

吴惠子, 刘洁. 乳腺癌的遗传药理学研究进展:内分泌治疗与化疗[J]. 中国临床药理学与治疗学, 2011, 16(3): 334-340.

WU Hui-zi, LIU Jie. Pharmacogenetics in breast cancer: hormone therapy and chemotherapy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(3): 334-340.

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