右美托嘧啶对硬膜外麻醉下阑尾手术牵拉反应的影响

中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (8): 912-915.

右美托嘧啶对硬膜外麻醉下阑尾手术牵拉反应的影响

陈公锦¹, 欧阳葆怡²

¹绍兴第二医院麻醉科, 绍兴312000, 浙江;
²广州医学院第一附属医院麻醉科, 广州510120, 广东

收稿日期:2011-05-14 修回日期:2011-08-01 出版日期:2011-08-26 发布日期:2011-09-07
作者简介:陈公锦, 男, 硕士,副主任医师,研究方向: 肌松药效应监测和肺隔离。E-mail: cgj0218@ 163.com

Efficacy of epidural anesthesia combined with dexmedetomidine on visceral traction response during appendectomy

CHEN Gong-jin¹, OU-YANG Bao-yi²

¹Department of Anesthesiology, Shaoxing Second Hospital, Shaoxing 312000, Zhejiang, China;
²Department of Anesthesiology, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120,Guangdong, China

Received:2011-05-14 Revised:2011-08-01 Online:2011-08-26 Published:2011-09-07

摘要/Abstract

摘要： 目的: 观察静脉使用右美托嘧啶对硬膜外麻醉下阑尾手术牵拉反应的预防效果。方法: 选择在硬膜外阻滞下进行阑尾切除术的患者80例,美国麻醉医师协会评级Ⅰ～Ⅱ,随机分为右美托嘧啶组与生理盐水对照组(对照组)每组40例。在切皮前 10 min 分别从静脉泵注 1 μg/kg 右美托嘧啶和相同剂量的生理盐水,输注时间均为 10 min,观察术中患者对牵拉阑尾的反应、用药前后血流动力学、呼吸及Ramsay镇静分级情况。结果: 右美托嘧啶组中阑尾手术牵拉反应明显降低,其优良率明显高于对照组(P<0.01),但右美托嘧啶组中心率在5、10和 15 min 明显低于对照组(P<0.01),右美托嘧啶组在用药后10、15和 30 min 时的Ramsay镇静分级明显高于对照组(P<0.01)。结论: 静脉给予 1 μg/kg 右美托嘧啶能有效预防硬膜外麻醉下阑尾手术牵拉反应。

关键词: 右美托嘧啶, 硬膜外麻醉, 阑尾切除术, 牵拉反应

Abstract: AIM: To evaluate the efficacy of epidural anesthesia versus intravenous dexmedetomidine on visceral traction response during appendectomy.METHODS: Eighty adult patients, American Society of Anesthesiology(ASA) physical status class Ⅰ-Ⅱ, undergoing appendectomy during epidural anesthesia were divided randomly into two groups that received 1 μg/kg dexmedetomidine (Dexmedetomidine Group) and the same volume normal saline(Control Group) intravenously for 10 min respectively. The visceral traction response of the patients, the changes of the MAP, HR and SpO₂, and the grade of Ramsay before and after dexmedetomidine or the normal saline was administered were evaluated during the operation.RESULTS: Intravenous dexmedetomidine could inhibit the visceral traction response during appendectomy, was superior to normal saline(P<0.01). The changes of MAP and SpO₂ in the two groups were not different, but HR was decreased significantly in Dexmedetomidine Group (P<0.01), the grades of Rassmay were increased significantly in Dexmedetomidine Group (P<0.01).CONCLUSION: Intravenous dexmedetomidine could inhibit the visceral traction response effectively during appendectomy.

Key words: Dexmedetomidine, Appendectomy, Ecphyadectomy, Visceral traction response

中图分类号:

R971⁺.2

陈公锦, 欧阳葆怡. 右美托嘧啶对硬膜外麻醉下阑尾手术牵拉反应的影响[J]. 中国临床药理学与治疗学, 2011, 16(8): 912-915.

CHEN Gong-jin, OU-YANG Bao-yi. Efficacy of epidural anesthesia combined with dexmedetomidine on visceral traction response during appendectomy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(8): 912-915.

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