内皮素心血管效应的研究进展

摘要/Abstract

摘要： 内皮素是迄今所知最强的缩血管物质,其广泛分布于外周组织和中枢神经系统,是调节心血管功能的重要因子,对维持基础血管张力与心血管系统稳态起重要作用。很多心血管疾病的发病机理都与内皮素系统功能异常有关。本文对近年来内皮素心血管效应研究进展进行综述。

关键词: 内皮素, 内皮素受体拮抗剂, 心血管效应

Abstract: Endothelin is the most powerful vasoconstrictor substance so far and widely distributed in peripheral tissue and central nervous system. It is an important factor in regulating cardiovascular function and keeping cardiovascular homeostasis and vascular tone. The pathogenesis of many cardiovascular diseases are associated with abnormal function of the endothelin system. This review summarizes the research progress of the cardiovascular effects of endothelin in recent years.

Key words: Endothelin, Endothelin receptor antagonists, Cardiovascular effects

中图分类号:

R966

陈艾东, 李娟, 谢海棠. 内皮素心血管效应的研究进展[J]. 中国临床药理学与治疗学, 2011, 16(8): 937-944.

CHEN Ai-dong, LI Juan, XIE Hai-tang. Recent research progress in cardiovascular effects of endothelin[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(8): 937-944.

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