蒙脱石作为药物载体的研究进展

中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (8): 956-960.

• 综述与讲座 • 上一篇

蒙脱石作为药物载体的研究进展

方颖颖, 郑高利

浙江省医学科学院,浙江 310013,杭州

收稿日期:2011-07-18 修回日期:2011-08-10 出版日期:2011-08-26 发布日期:2011-09-07
通讯作者: 郑高利,男,博士,研究员,硕士生导师,研究方向:中药药理学和新药开发与评价。Tel: 0571-88215620 E-mail: zhgl8686@163.com
作者简介:方颖颖,女,硕士研究生,研究方向:中药药理学。Tel: 0571-88215620 E-mail: fybabe@163.com

Research progress of montmorillonite as drug carriers

FANG Ying-ying, ZHENG Gao-li

Zhejiang Academy of Medical Science,Hangzhou 310013, Zhejiang,China

Received:2011-07-18 Revised:2011-08-10 Online:2011-08-26 Published:2011-09-07

摘要/Abstract

摘要： 天然蒙脱石是一种由膨润土提纯而来的非金属矿物,是一种2∶1型的粘土矿,即两个硅氧四面体亚层中间夹一个铝氧八面体亚层。该单位晶胞结构使其在医药领域的应用中具有独特的优势。蒙脱石作为一种性能良好的药用辅料,可应用于新型药物载体的开发,将有助于设计药物新剂型和寻找适宜的给药途径。本文综述了蒙脱石作为药物载体应用于医药领域的国内外最新研究进展。

关键词: 蒙脱石, 斑脱土, 药物载体, 药物运输系统

Abstract: Montmorillonite, refined from bentonite, is one type of nonmetallic minerals. It is a 2∶1 day, meaning that it has 2 tetrahedral sheets sandwiching a centrat octahedral sheet. It's the nuique crystal structure that gains an advantage in the applications of medical field. As a fine pharmaceutic excipient, it can be developed as new drug carriers to help design new drug formmlation and search for more suitable administration routes. This article reviews on the research progress of montmorillonite as drug carriers in recent years.

Key words: Montmorillonite, Bentonite, Drug carrier, Drug delivery system

中图分类号:

R977.5

方颖颖, 郑高利. 蒙脱石作为药物载体的研究进展[J]. 中国临床药理学与治疗学, 2011, 16(8): 956-960.

FANG Ying-ying, ZHENG Gao-li. Research progress of montmorillonite as drug carriers[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(8): 956-960.

参考文献

[1] 李海宁,王峻,何方领.蒙脱石的药用价值及存在问题[J].湖北农业科学,2003,(2):93-94.
[2] 王桂芳,吕宪俊.膨润土作为药用辅料的研究现状[J].金属矿山,2009(8):181-185.
[3] Jung H, Kim HM, Choy YB, et al. Laponite-based nanohybrid for enhanced solubility and controlled release of itraconazole[J]. Int J Pharm, 2008, 49(1/2):283-290.
[4] Bégu S, Aubert-Pouёssel A,Polexe R, et al. New layered double hydroxides/phospholipid bilayer hybrid material with strong potential for sustained drug delivery system[J].Chem Mater, 2009, 21(13): 2679-2687.
[5] Koeleman HA, Van Zyl. Influence of montmorillonite on the dissolution and bioavailability of phenytoin[J]. Drug Dev Ind Pharm,1990,16 (5):795-805.
[6] Aguzzi C, Cerezo P, Viseras C, et al. Use of clays as drug delivery systems: Possibilities and limitations[J].Applied Clay Science, 2007,36 (1/2/3): 22-36.
[7] 栾文楼,李明路.膨润土的开发利用[M].北京:地质出版社,1998:15-21.
[8] 潘兆橹,万朴.应用矿物学[M].武汉:大学工业出版社,1993:216-218.
[9] 廖才智. 聚合物/蒙脱土纳米复合材料研究进展[J]. 广东化工,2010,37(8):27-29.
[10] 王桂芳,吕宪俊,邱俊,等.氟尿嘧啶／蒙脱石复合物的制备及其释放性能[J].硅酸盐学报, 2010,38(4):136-141.
[11] 王桂芳,邱俊,吕宪俊,等.钙基蒙脱石对抗肿瘤新药卡莫氟的吸附及其缓释性能研究[J].矿物岩石,2010,30(1):8-13.
[12] Lin FH,LeeYH, Jian CH, et al. A study of purified montmorillonite intercalated with 5-fluorouracil as drug carrier[J]. Biomaterials, 2002, 23(9): 1981-1987.
[13] 杨超,皮振邦,田熙科.超细蒙脱石制备及其作为氟尿嘧啶药物控释载体的实验研究[J].武汉大学学报:理学版, 2002, 48(6): 652-654.
[14] 张彩云,鲁传华,方前锋,等.蒙脱石作为5-氟尿嘧啶药物缓释制剂载体的研究[J].非金属矿, 2010,33(5):44-46.
[15] Eiseman JL, Eddington ND, Leslie J, et al. Plasma pharmacokinetics and tissue distribution of paclitaxel in CD2F1 mice[J].Cancer Chemother Pharmacol,1994,34(6):65-471.
[16] Sun B, Ranganathan B, Feng SS. Multifunctionalpoly(d,l-lactide-co-glycolide) /montmorillonite (PLGA/MMT)nanoparticles decorated by Trastuzumab for targeted chemotherapy of breast cancer[J]. Biomaterials, 2008, 29(4): 475-486.
[17] Dong Y,i Feng SS. Poly(d, l-lactide-co-glycolide) /montmorillonite nanoparticles for oral delivery of anticancer drugs[J]. Biomaterials, 2005, 26(30): 6068-6076.
[18] Feng SS, Mei L,Anitha P, et al.Poly(lactide)-vitamin E derivative/montmorillonite nanoparticle formulations for the oral delivery of Docetaxel[J]. Biomaterials,2009,30(19):3297-3306.
[19] Makino S,Takehisa E,Akao N. Anthelmintics containing quaternary ammonium compounds:Kokai Tokkyo Koho, JP0952802[P].1997-02-25.
[20] Ghanshyam V. Radheshyam R, Bhavesh D, et al.Mesoporous synthetic hectorites:A versatile layered host with drug delivery application[J].Microporous Mesoporous Mater,2011,142(2/3):542-548.
[21] Park JK, Choy YB, Oh JM, et al. Controlled release of donepezil intercalated in smectite clays[J]. Pharm,2008,359(1/2):198-204.
[22] Ghanshyam V, Radheshyam R, Bhavesh D.Design and evaluation of controlled drug delivery system of buspirone using inorganic layered clay mineral[J]. Microporous Mesoporous Mater,2010,132(3):526-530.
[23] Youmei Chen, Anning Zhou, Bo Liu, et al.Tramadol hydrochloride/montmorillonite composite: Preparation and controlled drug release [J]. Appl Clay Sci, 2010, 49(3): 108-112.
[24] Zheng JP, Luan L, Wang HY. Study on ibuprofen/montmoril-lonite intercalation composites as drug release system[J]. Appl Clay Sci, 2007, 36(4): 297-301.
[25] 奚利飞.药物/蒙脱土缓释体系的制备和体外释放的研究 [D].天津:天津大学, 2004.
[26] 叶瑛.以坡缕石或蒙脱石为载体的补铬剂及其制备与使用方法:中国,CN1686558 [P]. 2005-10-26.
[27] 叶瑛,邬黛黛,季珊珊,等.以坡缕石、蒙脱石为载体的补锌剂及其制备使用方法:中国,CN1706499 [P].2005-12-14.
[28] Ghanshyam V.Joshi,Hasmukh A.Patel,Bhavesh D.Kevadiya,Hari C.Bajaj. Montmorillonite intercalated with vitamin B1 as drug carrier.[J].Applied Clay Science, 2009,45:248-253.
[29] Kevadiya BD, Joshi GV, Patel HA, et al. Montmorillonite-alginate nanocomposites as a drug delivery system: intercalation and in vitro release of vitamin B1 and vitamin B6[J]. J Biomater Appl 2010,25(2):161-177.
[30] Joshi GV, Kevadiya BD, Patel HA,et al.Montmorillonite as a drug delivery system: Intercalation and in vitro release of timolol maleate[J]. Int J Pharm, 2009,374(1/2):53-57.
[31] Madurai SL,Joseph SW.Intestine-specific,oral delivery of captopril/montmorillonite: formulation and release kinetics[J]. Nanoscale Re Lett,2011, 6(1):15.
[32] 周家宪,王志强.兽药蒙脱石的药用机制及价值[J].兽药与饲料添加剂,2009,4(6):19-20.
[33] Joshi GV, Kevadiya BD, Bajaj HC.Controlled release formulation of ranitidine-containing montmorillonite and Eudragit E-100[J]. Drug Dev Ind Pharm,2010, 36(9):1046-1053.
[34] Kevadiya BD, Joshi GV, Bajaj HC.Layered bionanocomposites as carrier for procainamide[J].Int J Pharm, 2010, 388(1/2):280-286.

蒙脱石作为药物载体的研究进展

Research progress of montmorillonite as drug carriers

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