二甲双胍延长寿命的作用及其作用机制

摘要/Abstract

摘要： 通过药理学方法来降低有机体的衰老率从而延长寿命已成为目前的研究热点之一。二甲双胍是一种用于治疗2型糖尿病的常用双胍类药物,研究显示二甲双胍可以延缓衰老并延长寿命,它可以通过激活腺苷酸活化蛋白激酶(AMPK)、抑制哺乳动物雷帕霉素靶蛋白(mTOR)及其下游相关分子发挥其抗衰老作用。本文对二甲双胍延长线虫、转基因小鼠和大鼠的寿命及其作用机制进行综述。

关键词: 二甲双胍, 延长寿命, 作用机制

Abstract: A research of pharmacological intervention that decreases the rate of organism aging to extend their life span is a perspective direction. Several studies have shown that metformin which is a biguanide class drug used in the treatment of type 2 diabetes mellitus can slow down aging and prolong life span.The possible mechanisms may be related to AMPK activation, mTOR inhibition and its downstream molecules.This review describes the effects of metformin on lifespan extension in nematode, transgenic mice , rats and potential mechanisms.

Key words: Metformin, Lifespan extension, Mechanisms

中图分类号:

齐赫, 刘亭亭, 李国荣. 二甲双胍延长寿命的作用及其作用机制[J]. 中国临床药理学与治疗学, 2012, 17(11): 1295-1301.

QI He, LIU Ting-ting, LI Guo-rong. Effects and mechanisms of metformin on lifespan extension[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(11): 1295-1301.

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