小剂量米非司酮治疗经前期综合征的随机双盲对照研究

中国临床药理学与治疗学 ›› 2012, Vol. 17 ›› Issue (12): 1398-1400.

小剂量米非司酮治疗经前期综合征的随机双盲对照研究

周春慧, 杨白兰, 杨章莉, 龙文香

株洲市妇幼保健院妇产科, 株洲 412000,湖南

收稿日期:2012-10-19 修回日期:2012-12-12 发布日期:2012-12-31
通讯作者: 杨章莉,通信作者,女,硕士,主治医师,研究方向:生殖内分泌。Tel: 0731-28208909 E-mail: zhangliyang2005624@163.com
作者简介:武海云,女,硕士,研究方向:分子药理学。Tel: 0551-5169371 　E-mail: hettier@163.com

Double blinded randomized and controlled study on premenstrual syndrome by Mifepristone

ZHOU Chun-hui, YANG Bai-lan, YANG Zhang-li, LONG Wen-xiang

Department of Gynaecology and Obstetrics,Children and Women's Health Hospital of Zhuhzou,Zhuzhou 412000,Hunan,China

Received:2012-10-19 Revised:2012-12-12 Published:2012-12-31

摘要/Abstract

摘要： 目的: 观察小剂量米非司酮治疗经前期综合征的临床疗效和安全性。方法: 采用随机双盲安慰剂对照试验设计方法,选择80例经前期综合征患者,随机分为研究组和对照组,每组40例。每组均连续用药1个疗程(3个月经周期),并予以随访3个月经周期。结果: 研究组与对照组临床疗效的总有效率分别为92.5%(37/40)和45%(18/40),2组比较有统计学差异(P<0.05),研究组优于对照组。研究组与对照组随访3个月经周期临床疗效的总有效率分别为90%(36/40)和37.5%(15/40),2组比较有统计学差异(P<0.05),研究组优于对照组。研究组和对照组均无明显不良反应。结论: 小剂量米非司酮能缓解经前期综合征症状,具有明显疗效,且副作用小,有一定安全性。

关键词: 经前期综合征, 米非司酮, 随机双盲设计

Abstract: AIM: To evaluate the efficacy and safety of Mifepristone in treating patients with premenstrual syndrome(PMS). METHODS: 80 subjects diagnosed with PMS were participated in the study. The study was designed as randomized double blind placebo controlled trial. The experimental group was treated with Mifepristone for 3 months, while controlled with placebo. And a 3-month follow up for effectiveness and safety would be taken and experimental.RESULTS: The total effective rates of experimental and controlled were 92.5% and 45% respectively, and the total clinical effect rates of 3-month follow up were 90% and 37.5% respectively, comparisons of the two indices were significantly different(P<0.05). As for safety, there was no significant difference.CONCLUSION: Mifepristone can improve the PMS. And its effect is obvious, with more safety less side effects in treating PMS.

Key words: Premenstrual syndrome, Mifepristone, Double blinded randomized design

中图分类号:

R711

周春慧, 杨白兰, 杨章莉, 龙文香. 小剂量米非司酮治疗经前期综合征的随机双盲对照研究[J]. 中国临床药理学与治疗学, 2012, 17(12): 1398-1400.

ZHOU Chun-hui, YANG Bai-lan, YANG Zhang-li, LONG Wen-xiang. Double blinded randomized and controlled study on premenstrual syndrome by Mifepristone[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(12): 1398-1400.

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