炎症信号在脑-肠轴中的传递及药物干预机制研究进展

中国临床药理学与治疗学 ›› 2012, Vol. 17 ›› Issue (12): 1407-1412.

炎症信号在脑-肠轴中的传递及药物干预机制研究进展

康安^1,2, 郑啸², 文红梅³, 王小龙¹

¹南京中医药大学药学院药物分析教研室,南京 210046,江苏;
²天然药物活性组分与功效国家重点实验室(中国药科大学),南京 210023,江苏;
³南京中医药大学药学院分析测试中心,南京 210023,江苏

收稿日期:2012-10-25 修回日期:2012-11-20 发布日期:2012-12-31
通讯作者: 王小龙,通信作者,男,博士,教授,硕士生导师,研究方向:天然药物全合成及药效评价。Tel: 025-85811512 E-mail: x.greg.wang@gmail.com
作者简介:康安,男,博士,讲师,研究方向:中药药理学与药代动力学。Tel: 025-85311053 　E-mail: kangan2008@yahoo.com.cn
基金资助:
国家自然科学基金项目(81202983); 天然药物活性组分与功效国家重点实验室(中国药科大学)资助项目(SKLNMKF201209); 南京中医药大学青年自然科学基金项目(11XZR09)

Transmission of inflammatory signals along the [brain gut] advances and intervention strategies

KANG An^{1, 2}, ZHENG Xiao², WEN Hong-mei³, WANG Xiao-long¹

¹Pharmaceutical Analysis Section,School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046,Jiangsu,China;
²State Key Laboratory of Natural Medicines, China Pharmaceutical University ,Nanjing 210046,Jiangsu,China;
³Analysis and Test Center, School of pharmacy, Nanjing University of Chinese Medicine,Nanjing 210046,Jiangsu,China

Received:2012-10-25 Revised:2012-11-20 Published:2012-12-31

摘要/Abstract

摘要： 中枢神经系统疾病与某些外周疾病具有共生的特点,由“脑-肠轴”介导的炎症信号在外周和中枢间的传递被认为是联系中枢系统疾病与外周炎症的重要途径,这一机制对于全面认识中枢神经系统疾病的发病机制以及相关疾病的预防和治疗具有重要意义。本文就“脑-肠轴”介导的炎症信号传递对神经精神疾病,尤其是抑郁症的影响及其机制进行了综述,并探讨了干预“脑-肠轴”炎症信号对于中枢神经系统疾病的预防和治疗的潜在前景。

关键词: 脑肠轴, 炎症, 抑郁

Abstract: Accumulating evidence reveals a close linkage between the central nervous system disorders and the peripheral diseases. It is believed that the “brain-gut axis” mediated inflammatory signal transmission is an important pathway to link the brain disorders and peripheral inflammation.In this review, we discusse the potential mechanisms involved in the inflammatory signal transmission along the “brain-gut axis” and its influence on the subsequently developed neuropsychiatric disorders especially major depression. Also the potential strategies to intervene the inflammatory signal transmission along the “brain-gut axis” for the prevention and treatment of brain disorders are discussed in this paper.

Key words: Brain-gut axis, Inflammation, Depression

中图分类号:

R593

康安, 郑啸, 文红梅, 王小龙. 炎症信号在脑-肠轴中的传递及药物干预机制研究进展[J]. 中国临床药理学与治疗学, 2012, 17(12): 1407-1412.

KANG An, ZHENG Xiao, WEN Hong-mei, WANG Xiao-long. Transmission of inflammatory signals along the [brain gut] advances and intervention strategies[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(12): 1407-1412.

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