疏血通与丹参对脑梗死患者及其高危人群血液流变学影响的Meta分析

中国临床药理学与治疗学 ›› 2012, Vol. 17 ›› Issue (3): 302-307.

疏血通与丹参对脑梗死患者及其高危人群血液流变学影响的Meta分析

颜陶, 周岐新, 费慧芝, 胡小娅, 杨秋珺

重庆医科大学药学院药理学教研室,重庆 400016

收稿日期:2011-10-10 修回日期:2011-11-23 出版日期:2012-03-26 发布日期:2012-04-20
通讯作者: 周岐新,男,教授,博士生导师,研究方向:神经精神药理学和临床药理学。Tel: 023-68485038, E-mail: cqzhouqx@yahoo.com.cn
作者简介:颜陶,男,硕士研究生,医师,主要从事临床药理学和循证医学研究。E-mail: 76300472@qq.com

A Meta-analysis for hemorrheologic parameters in patients with cerebral infarction or high risk population treated by Shuxuetong or Danshen

YAN Tao, ZHOU Qi-xin, FEI Hui-zhi, HU Xiao-ya, YANG Qiu-jun

Department of Pharmacology, Chongqing Medical University, Chongqing 400016, China

Received:2011-10-10 Revised:2011-11-23 Online:2012-03-26 Published:2012-04-20

摘要/Abstract

摘要： 目的: 比较疏血通与丹参在改善脑梗死患者及其高危人群血流状态的差异,为临床用药提供循证医学依据。方法: 通过检索2000-2011年国内发表的文献,按纳入排除标准筛选,得到符合研究条件的文献13篇,用Meta分析方法处理文献中的数据。结果: 疏血通组与丹参组比较:全血高切黏度(mPa·s):WMD=-0.53,95%CI (-0.76, -0.31),P<0.05;全血低切黏度(mPa·s):WMD=-1.40,95%CI (-2.05 , -0.74),P<0.05;血浆黏度(mPa·s):WMD=-0.27,95%CI (-0.39, -0.15),P<0.05;纤维蛋白原(g/L):WMD=-0.75,95%CI (-0.97, -0.52),P<0.05;红细胞压积:WMD=-0.05,95%CI (-0.08, -0.01),P<0.05。结论: 疏血通对血液流变学各项指标的影响均优于丹参,但文献的异质性较大。

关键词: 疏血通, 丹参, 血液流变学, 脑梗死, 高危, Meta分析, 循证医学

Abstract: AIM: To compare effects of Shuxuetong on hemorrheologic parameters to that of Danshen in patients with cerebral infarction or high risk population, so that evidences in Evidence-based Medicine can be provided for clinical pharmacotherapy. METHODS: Thirteen articles corresponding to our researching condition were searched out by retrieving and screening domestic articles from 2000 to 2011 according to the criterion for including or excluding articles. The data were processed by the method of meta-analysis. RESULTS: A comparison between Shuxuetong versus Danshen: HS [WMD=-0.53, 95%CI (-0.76, -0.31), P<0.05]; LS [WMD=-1.40, 95%CI (-2.05, -0.74), P<0.05]; PV [WMD=-0.27, 95%CI (-0.39, -0.15), P<0.05]; FIB [WMD=-0.75, 95%CI (-0.97, -0.52), P<0.05]; HCT [WMD=-0.05, 95%CI (-0.08, -0.01), P<0.05]. CONCLUSION: The improvement effects of Shuxuetong on hemorrheologic parameters are better than that of Danshen, even though serious heterogeneity exists among the selected articles.

Key words: Shuxuetong, Danshen, Hemorrheology, Cerebral infarction, High risk, Meta-analysis, Evidence-based medicine

中图分类号:

颜陶, 周岐新, 费慧芝, 胡小娅, 杨秋珺. 疏血通与丹参对脑梗死患者及其高危人群血液流变学影响的Meta分析[J]. 中国临床药理学与治疗学, 2012, 17(3): 302-307.

YAN Tao, ZHOU Qi-xin, FEI Hui-zhi, HU Xiao-ya, YANG Qiu-jun. A Meta-analysis for hemorrheologic parameters in patients with cerebral infarction or high risk population treated by Shuxuetong or Danshen[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(3): 302-307.

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