卡巴胆碱联合胸腺素对多器官功能障碍综合征病人细胞免疫功能的影响

中国临床药理学与治疗学 ›› 2012, Vol. 17 ›› Issue (6): 677-681.

卡巴胆碱联合胸腺素对多器官功能障碍综合征病人细胞免疫功能的影响

程爱斌, 尚秀娟, 王瑞刚, 刁増利, 张军伟

河北联合大学附属医院,重症医学科,唐山 063000,河北

收稿日期:2011-10-25 修回日期:2012-01-05 出版日期:2012-06-26 发布日期:2012-06-25

Effect of carbachol and thymosin on the function of cell-ular immune in patients with multiple organ dysfunction

CHENG Ai-bin, SHANG Xiu-juan, WANG Rui-gang, DIAO Zeng-li, ZHANG Jun-wei

Department of Intensive Care Unit, the Affiliated Hospital of Hebei United University, Tangshan 063000, Hebei, China

Received:2011-10-25 Revised:2012-01-05 Online:2012-06-26 Published:2012-06-25
About author:CHEN Ai-bin, male, Ph.D., associate professor, deputy chief physician, mainly engaged in inintestical protection of critvcaly in patiewts. Tel: 13313150909 E-mail: myfyicu@126.com

摘要/Abstract

摘要： 目的: 研究卡巴胆碱和胸腺素对多器官功能障碍综合征(MODS)患者细胞免疫功能的影响。方法: 随机将MIDS患者208例分为正常治疗组、卡巴胆碱组、胸腺素组和联合治疗组,用流式细胞仪测量HLA-DR及淋巴细胞凋亡的变化。结果: 正常治疗组与其他治疗组相比,差异有统计学意义(P<0.05)、卡巴胆碱组与胸腺素组相比,差异无统计学意义(P>0.05)；联合治疗组与其他组比较差异亦有统计学意义(P<0.05)。卡巴胆碱和胸腺素治疗可以提高MODS病人的免疫功能,联合使用效果更佳。结论: 卡巴胆碱和胸腺素在MODS病人的治疗中有一定价值。

关键词: 卡巴胆碱, 胸腺素, 多脏器功能不全综合征, 人类白细胞组织抗原, 凋亡

Abstract: AIM: To study carbachol and thymosin on cellular immune function in patients with MODS. METHODS: 208 cases of MODS patients were selected, which were randomly divided into the normal treatment group, carbachol group, thymosin group and the combined treatment group. Using flow cytometry to test the changes of CD₁₄⁺ monocots human leukocyte antigen DR (HLA-DR) and Lymphocyte apoptosis. RESULTS: Normal treatment group was compared with the other treatment groups, the difference was statistically significant (P<0.05); carbachol group was compared with the thymosin group, the difference was not statistically significant (P>0.05); the combination therapy group comparing with other groups,the difference was also significant (P<0.05). Carbachol and thymosin can enhance immune function in patients with MODS, combined treatment doing better effect. CONCLUSION: Carbachol and thymosin has some clinical value on the treatment of MODS.

Key words: Carbachol, Thymosin, MODS, HLA-DR, Apoptosis

中图分类号:

R968

程爱斌, 尚秀娟, 王瑞刚, 刁増利, 张军伟. 卡巴胆碱联合胸腺素对多器官功能障碍综合征病人细胞免疫功能的影响[J]. 中国临床药理学与治疗学, 2012, 17(6): 677-681.

CHENG Ai-bin, SHANG Xiu-juan, WANG Rui-gang, DIAO Zeng-li, ZHANG Jun-wei. Effect of carbachol and thymosin on the function of cell-ular immune in patients with multiple organ dysfunction[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(6): 677-681.

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