组胺基因组学研究进展

中国临床药理学与治疗学 ›› 2012, Vol. 17 ›› Issue (6): 703-708.

组胺基因组学研究进展

石盼盼^1,2, 何功浩¹, 徐贵丽¹

¹成都军区昆明总医院,昆明 650032,云南;
²昆明医科大学,昆明 650031,云南

收稿日期:2012-02-08 修回日期:2012-05-08 出版日期:2012-06-26 发布日期:2012-06-25
通讯作者: 徐贵丽,女,博士,主任药师,硕士生导师,研究方向:药代动力学及药物基因组学。E-mail: xuguili@126.com
作者简介:石盼盼,女,在读硕士研究生,研究方向:组胺基因组学。

Research advances of Histamine Pharmacogenomics

SHI Pan-pan^1,2, HE Gong-hao¹, XU Gui-li¹

¹Department of Pharmacy, Kunming General Hospital of Chengdu Military Region, Kunming 650032, Yunnan, China;
²Kunming Medical Univercity, Kunming 650031, Yunnan, China

Received:2012-02-08 Revised:2012-05-08 Online:2012-06-26 Published:2012-06-25

摘要/Abstract

摘要： 组胺是机体重要的自体活性物质之一,经其各型受体介导参与多种生理病理过程。随着人类基因组计划及国际人类单体型图项目的完成,组胺相关基因多态性与疾病的关联性研究日渐成为国内外学者研究热点。本文就目前国内外关于组胺相关基因多态性研究现状进行了综述,以期为后续研究组胺相关基因与疾病的关联性提供较为系统的文献基础。

关键词: 组胺, 组氨酸脱羧酶基因, 组胺N-甲基转移酶基因, 二胺氧化酶基因, 组胺受体

Abstract: Histamine, one of the essential active substances of the autologous, which involves in the physiological and pathological procedures by every receptor.Along with the completion of the HGP project and the human haplotype diagram, the genic polymorphism and the correlation of the disease concerned with the histamine becomes a hot subject in both domestic and international academy. This article summarizes the present study of the histamine with its relative genic polymorphism, aiming to provide a systematic and fundamental document for the follow-up research of Histamine.

Key words: Histamine, HDC, HNMT, DAO, Histamine receptor

中图分类号:

R968

石盼盼, 何功浩, 徐贵丽. 组胺基因组学研究进展[J]. 中国临床药理学与治疗学, 2012, 17(6): 703-708.

SHI Pan-pan, HE Gong-hao, XU Gui-li. Research advances of Histamine Pharmacogenomics[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(6): 703-708.

参考文献

[1] 俞朝阳.脑内组胺、多巴胺能神经在吗啡诱导的条件未知偏爱试验中的作用[J].中国药理学通报,2005,21(9):1049-1053.
[2] SNPs. www.ncbi.nlm.nih.gov/projects/SNP.
[3] Zhang F, Xiong DH, Wang W, et al. HDC gene polymorphisms are associated with age at natural menopause in Caucasian women[J]. Biochem Biomass Res Common, 2006, 348(4): 1378-1382.
[4] 孙效玢. 组胺脱羧酶基因多态性与原发性高血压的关系[J]. 中国公共卫生管理,2006, 1(22): 55-56.
[5] Pervasive G, Ago deal JAG, Garcl a-Senate J, et al. Amiability of human examine oxidase: occurrence of three nonsynonymous polymorphisms and Variability of the L-Histidine decarboxylase gene in allergic rhinitis[J]. Allergy, 2010,65(12): 1576-1584.
[6] Sieja K, Stanosz S, von Mach-Szczypinski J, et al. Concentration of histamine in serum and tissues of the primary ductal breast cancers in women[J]. Breast, 2005,14(3):236-241.
[7] García-Martín E, Ayuso P, Martínez C, et al. Improved analytical sensitivity reveals the occurrence of gender-related variability in diamine oxidase enzyme activity in healthy individuals[J]. Clin Biochem, 2007, 40(16/17): 1339-1341.
[8] Ayuso P, García-Martín E, Martínez C, et al. Genetic variability of human diamine oxidase: occurrence of three nonsynonymous polymorphisms and study of their effect on serum enzyme activity[J]. Pharmacogenet Genomics, 2007,17(9): 687-693.
[9] Maintz L, Yu C-F, Baurecht H, et al. Association of single nucleotide polymorphisms in thediamine oxidase gene with diamine oxidase serum activities[J]. Allergy, 2011,66(7): 893-902.
[10] 王红姗. 人原发性肝癌组织中HDC、HNMT和DAO基因表达及意义[D]. 广西: 广西医科大学,2004.
[11] Mennigen R, Kusche J, Streffer C, et al.Diamine oxidase activities in the large bowel mucosa of ulcerative colitis patients[J]. Agents Actions,1990,30(1/2): 264-266.
[12] Barnes WG, Grinde E, Crawford DR, et al. Characterization of a new mRNA species from the human histamine N-methyltransferase gene[J]. Genomics,2004, 83(1): 168-171.
[13] Preuss CV, Wood TC, Szumlanski CL,et al. Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity[J]. Mol Pharmacol, 1998,53(4): 708-717.
[14] Palada V,Terzic J,Mazzulli J,et al. Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease[J]. Neurobiol Aging, 2012, 33(4): 836-841.
[15] Yan L, Galinsky RE, Bernstein JA, et al. Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma[J]. Pharmacogenetics, 2000,10(3): 261-266.
[16] Lee HS,Kim SH,Kim KW,et al. Involvement of human histamine N-methyltransferase gene polymorphisms in susceptibility to atopic dermatitis in korean children[J]. Allergy Asthma Immunol Res,2012,4(1):31-36.
[17] Agundez JA, Luengo A, Herraez O, et al. Nonsynonymous polymorphisms of histamine-metabolising enzymes in patientswith Parkinson's disease[J]. Neuromolecular Med, 2008,10(1):10-16.
[18] García-Martín E, Ayuso P, Luengo A, et al. Genetic variability of histamine receptors in patients with Parkinson's disease[J]. BMC Med Genet, 2008, 9: 15.
[19] Hiroyuki. Histamine H₁ Receptor Gene as an Allergic Diseases-sensitive Gene and Its Impact on Therapeutics for Allergic Diseases[J]. J Pept Sci, 2011,131(2): 171-178.
[20] Stoyanov E, Uddin M, Mankuta D, et al. Mast cells and histamine enhance the proliferation of non-small cell lung cancer cells[J]. Lung Cancer, 2012, 75(1): 38-44.
[21] Medina VA,Rivera ES. Histamine receptors and cancer pharmacology[J]. Br J Pharmacol, 2010, 161(4): 755-767.
[22] He G, Hu J. Sympathetic histamine exerts different pre- and post-synaptic functions according to the frequencies of nerve stimulation in guinea pig vas deferens[J]. J Neurochem, 2008,106(4): 1710-1719.
[23] Kapoor S, Pal S, Sahni P, et al. Effect of pre-operative short course famotidine on tumor in? ltrating lymphocytes in colorectal cancer: a double blind, placebo controlled, prospective randomized study[J]. J Surg Res, 2005,129(2): 172-175.
[24] Tomita K, Izumi K, Okabe S. Roxatidine and cimetidine induced angiogenesis inhibition suppresses growth of colon cancer implants in syngeneic mice[J]. J Pharmacol Sci, 2003, 93(3): 321-330.
[25] Haas HL, Sergeeva OA, Selbach O. Histamine in the nervous system[J]. Physiol Rev, 2008, 88(3): 1183-241.
[26] Levi R, Smith NC. Histamine H(3)-receptors: a new frontier in myocardial ischemia[J]. J Pharmacol Exp Ther, 2000,292(3): 825-830.
[27] He G, Hu J, Li T, et al. The arrhythmogenic effect of sympathetic histamine in mouse hearts subjected to acute ischemia[J]. Mol Med,2012, 18(1): 1-9.
[28] Medina VA, Croci M, Crescenti E, et al. The role of istamine in human mammary carcinogenesis: H3 and H4 receptors as potential therapeutic targets for breast cancer treatment[J]. Cancer Biol Ther, 2008, 7(1): 28-35.
[29] Wei Z, Wang L, Zhang M, et al. A pharmacogenetic study of risperidone on histamine H3 receptor gene(HRH3) in Chinese Han schizophrenia patients[J]. J Psychopharmacol, 2011.
[30] Chao Z, Yi X, Jiang L, et al. Deletion and Down-Regulation of HRH4 Gene in Gastric Carcinomas: A Potential Correlation with Tumor Progression[J]. Plos One, 2012, 7(2):e31207.
[31] Mommert S, Gschwandtner M, Gutzmer R, et al. The role of the histamine h4 receptor in atopic dermatitis[J].Curr Allergy Asthma Rep, 2011, 11(1): 21-28.
[32] Yu B, Shao Y, Li P,et al. Copy number variations of the human histamine H4 receptor gene are associated with systemic lupus erythematosus[J]. Br J Dermatol, 2010, 163(5): 935-940.
[33] Yu B, Shao Y, Zhang J,et al. Polymorphisms in human histamine receptor H4 gene are associated with atopic dermatitis [J]. Br J Dermatol,2010,162(5):1038-1043.
[34] Lee SY, McLeod HL. Pharmacogenetic tests in cancer chemotherapy: what physicians should know for clinical application[J]. J Pathol, 2011,223(1): 15-27.