代谢组学在肝肾损伤研究中的应用

摘要/Abstract

摘要： 代谢组学是近年来新发展起来的一门组学,已成为生物医学研究领域的新热点。由于其广泛的应用前景,目前已是系统生物学的重要组成部分。肝损伤及肾损伤是临床常见的危害人类健康的疾病,但目前的指标缺乏特异性,且灵敏度不高,造成临床上难以对肝肾损伤做出准确而及时的预警和监测。代谢组学能从代谢的角度整体分析疾病,快速、安全地对疾病的严重程度进行判别,在肝肾损伤的早期诊断等方面的研究已初显优势。本文主要综述了代谢组学技术在肝肾损伤研究中的应用现状。

关键词: 代谢组学, 肝损伤, 肾损伤, 进展

Abstract: Metabonomics is a new developing “omics” in recent years, which has become one of the most active research areas in biomedical field. Due to its promising applications in many fields, metabonomics has been becoming an important component of system biology. Liver injury and kidney injury are common clinical diseases that endanger human health. However, current indicators are lacking of specificity and sensitivity, so that it is difficult to make accurate, timely warning and monitoring. Metabonomics will contribute to comprehensive analysis of diseases from the perspective of metabolic, distinguishing severity of the disease fast and safely, with the result that there can be seen an increasing advantages for the research on the early diagnosis of liver and kidney injury. This paper mainly reviewed the recent application process of metabonomics in liver and kidney injury research.

Key words: Metabonomics, Liver injury, Kidney injury, Recent development

中图分类号:

R969.1

何睦, 姚卫峰, 蔡秀江, 丁安伟, 蒋叶娟. 代谢组学在肝肾损伤研究中的应用[J]. 中国临床药理学与治疗学, 2012, 17(8): 924-930.

HE Mu, YAO Wei-feng, CAI Xiu-jiang, DING An-wei, JIANG Ye-juan. Application of metabonomics in liver and kidney injury research[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(8): 924-930.

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