胡桃醌对小鼠黑色素瘤细胞B16F10体内迁移的影响

中国临床药理学与治疗学 ›› 2012, Vol. 17 ›› Issue (9): 978-982.

胡桃醌对小鼠黑色素瘤细胞B16F10体内迁移的影响

陈丽¹, 张建², 汪思应¹, 黄德武¹, 顾为望²

¹安徽医科大学实验动物中心,合肥 230032,安徽;
²南方医科大学实验动物中心暨比较医学研究所,广州 510515,广东

收稿日期:2011-12-27 修回日期:2012-08-02 发布日期:2012-09-25
通讯作者: 顾为望,通信作者,男,研究方向: 转基因动物制作、比较医学研究、实验动物新品种培育。
作者简介:陈丽,女,讲师,研究方向:比较医学。Tel: 0551-5167715 E-mail: yaligj@126.com
基金资助:
安徽医科大学校博士科研资助经费(XJ200906)

The inhibitory effect of juglone on the metastasis of skin melanoma cell line B16F10

CHEN Li¹, ZHANG Jian², WANG Si-ying¹, HUANG De-wu¹, GU Wei-wang²

¹Laboratory Animal Center,Anhui Medical University,Hefei 230032, Anhui,China;
²Laboratory Animal Center&Department of Comparative Medicine, Southern Medical University, Guangzhou 510515, Guangdong,China;

Received:2011-12-27 Revised:2012-08-02 Published:2012-09-25

摘要/Abstract

摘要： 目的研究胡桃醌对小鼠黑色素瘤细胞B16F10体内迁移的影响。方法采用小鼠B16/F10黑色素瘤人工肺转移模型研究胡桃醌对肿瘤细胞血道转移的作用。结果与溶剂对照组相比,4.5、3、1.5 和 0.75 mg/kg 胡桃醌组显著减少小鼠黑色素瘤B16F10血道转移(P<0.05),其抑制率分别为 27.30%、55.35%、31.52%和 25.34%;3 mg/kg 胡桃醌与阳性对照组相比,抑瘤率无统计学差异(P>0.05)。结论胡桃醌可抑制小鼠黑色素瘤B16F10血道转移。

关键词: 胡桃醌, B16F10, 血道转移

Abstract: AIM: To investigate the inhibitory effect of juglone on the metastasis of skin melanoma cell line B16F10. METHODS: B16-F10 cells were injected into the tail veins of C57BL/6 mice to establish an experimental lung metastasis model, and the effect of juglone on lung metastasis was observed.RESULTS: The number of metastases in the animals that were given juglone 4.5,3,1.5 and 7.5 mg·kg^-1·d^-1 was significantly reduced as compared with the vehicle control(P<0.05),and the inhibition rates were 27.30%, 55.35%, 31.52%, 25.34%, respectively.Compared with the positive control group, the inhibitory rate of 3 mg/kg juglone was no significant difference (P>0.05). CONCLUSION: Juglone could inhibit melanoma metastasis of B16F10.

Key words: Juglone, B16F10 cell, Hematogenous metastasis

中图分类号:

R965.2

陈丽, 张建, 汪思应, 黄德武, 顾为望. 胡桃醌对小鼠黑色素瘤细胞B16F10体内迁移的影响[J]. 中国临床药理学与治疗学, 2012, 17(9): 978-982.

CHEN Li, ZHANG Jian, WANG Si-ying, HUANG De-wu, GU Wei-wang. The inhibitory effect of juglone on the metastasis of skin melanoma cell line B16F10[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(9): 978-982.

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