混合促进剂在经皮给药中的应用研究进展

摘要/Abstract

摘要： 研究表明混合促进剂对药物具有良好的促透效果,克服了使用单个化学促进剂的不足,随着对其促透机制和处方高通量筛选方法的进一步研究,混合促进剂在经皮给药系统中将有更好的发展前景。本文依据近年来国内外相关文献,从药物在皮肤的转运、化学促进剂及混合促进剂对药物的促透机制、处方筛选和实践应用等方面对混合促进剂在经皮给药系统中的应用研究进展进行综述。

关键词: 混合促进剂, 协同作用, 高通量筛选, 经皮给药

Abstract: Research study showed that multi-component mixtures of enhancers had significant permeation enhancing ability than permeation enhancers alone, with low skin irritancy and low systemic toxicity. It can be concluded that multi-component mixtures of enhancers, will have a better development, while taking further research on permeation enhancement mechanism and high-throughput screening method. According to domestic and foreign literatures, application of multi-component mixtures of enhancers in transdermal drug delivery were presented. The review focused on the following aspects: (1) drug transport across skin; (2) permeation enhancement mechanism; (3) high-throughput screening of transdermal formulations and application practice.

Key words: Multi-component mixtures of enhancers, Synergistic effect, High-throughput screening, Transdermal drug delivery

中图分类号:

R943

俞文英, 张亮, 陈国神, 叶金翠. 混合促进剂在经皮给药中的应用研究进展[J]. 中国临床药理学与治疗学, 2013, 18(1): 103-109.

YU Wen-ying, ZHANG Liang, CHEN Guo-shen, YE Jin-cui. Research progress in application of multi-component mixtures of enhancers in transdermal drug delivery[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(1): 103-109.

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