华蟾素联合光动力学疗法对H22肝癌小鼠胃动素、胃泌素影响的实验研究

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (1): 30-33.

华蟾素联合光动力学疗法对H₂₂肝癌小鼠胃动素、胃泌素影响的实验研究

宋利斌¹, 何登全², 沈敏鹤¹

¹浙江中医药大学第一附属医院肿瘤中心,杭州310006,浙江;
²义乌市中医院,义乌322000,浙江

收稿日期:2012-07-07 修回日期:2012-07-07 发布日期:2013-02-05
通讯作者: 沈敏鹤,通信作者,男,主任医师,博士生导师,研究方向:中医恶性肿瘤的预防与治疗。E-mail: smh3288@yahoo.com.cn
作者简介:宋利斌,男,博士研究生,主治医师,主要从事恶性肿瘤的中医药预防与治疗。 Tel: 13588728969 E-mail: czsll@126.com
基金资助:
浙江省义乌市科技计划项目(2010-43)

Empirical study of photodynamic therapy combined with cinobufotalin on transplanted H₂₂ liver cancer by observing its influence on motilin,gastrin

SONG Li-bin¹, HE Deng-quan², SHEN Min-he¹

¹Department of Oncology, the First Affiliated Hospital of Zhe Jiang Chinese Medical University,Hangzhou 310006,Zhejiang,China;
²Yiwu Traditional Chinese Medicine Hospital,Yiwu 322000,Zhejiang,China

Received:2012-07-07 Revised:2012-07-07 Published:2013-02-05

摘要/Abstract

摘要： 目的: 探讨华蟾素联合光动力学疗法(PDT)对荷H₂₂肝癌小鼠胃动素、胃泌素的影响。方法: 采用甲脂化叶绿素(MECD)光敏剂联合华蟾素治疗移植性H₂₂肝癌小鼠,测定其抑瘤率及胃动素、胃泌素水平。结果: PDT联合华蟾素组、华蟾素组、PDT组的抑瘤率分别为 51.69%、33.49%、26.50%, PDT治疗后可以使胃动素、胃泌素保持在一定的水平,并减轻化疗引起的呕吐、恶心等消化道反应。结论: 华蟾素联合光动力学疗法可增强H₂₂肝癌小鼠的杀伤效应,同时能明显改善小鼠整体情况,无明显不良反应和副作用,具有可行意义,值得推荐。

关键词: 甲酯化叶绿素(MECD), 光动力学疗法(PDT), 华蟾素, 胃动素, 胃泌素

Abstract: AIM: To discuss the effect of photodynamic therapy(PDT)combined with anti-cancerdrugs cinobufotalin on transplanted H₂₂ liver cancer by observing its influence on motilin,gastrin. METHODS: The tumor inhibition rate and the levels of gastrin and motilin after Methyl esterification of chlorophyll (MECD)combined with cinobufotalin treating transplanted H₂₂ liver cancer were determined.RESULTS: The inhibitory rate of PDT combined with cinobufotalin Group,cinobufotalin Group, PDT Group was 51.69%,33.49%,26.50%,respectively.The motilin and gastrin were maintained at a certain level treated with PDT, it could reduce digestive tract reaction,such as nausea and vomit.CONCLUSION: Experiments show that PDT combined with cinobufotalin can strengthen obviously photosensitive killing effect on mice transplanted H₂₂ liver cancer, meanwhile,it can improve significantly the overall situation of mice. It has a practical significance and deserves recommendation.

Key words: Methyl esterification of chlorophyll (MECD), Photodynamic therapy(PDT), Cinobufotalin, Motilin, Gastrin

中图分类号:

R965.2

宋利斌, 何登全, 沈敏鹤. 华蟾素联合光动力学疗法对H₂₂肝癌小鼠胃动素、胃泌素影响的实验研究[J]. 中国临床药理学与治疗学, 2013, 18(1): 30-33.

SONG Li-bin, HE Deng-quan, SHEN Min-he. Empirical study of photodynamic therapy combined with cinobufotalin on transplanted H₂₂ liver cancer by observing its influence on motilin,gastrin[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(1): 30-33.

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华蟾素联合光动力学疗法对H₂₂肝癌小鼠胃动素、胃泌素影响的实验研究

Empirical study of photodynamic therapy combined with cinobufotalin on transplanted H₂₂ liver cancer by observing its influence on motilin,gastrin

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