细辛脑注射液治疗小儿喘息性支气管炎临床疗效的Meta分析

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (1): 39-45.

细辛脑注射液治疗小儿喘息性支气管炎临床疗效的Meta分析

徐喆¹, 陈群¹, 濮之晨¹, 胡骅¹, 谢海棠^1,2

¹皖南医学院研究生部,²皖南医学院弋矶山医院临床药学部,芜湖 241000,安徽

收稿日期:2012-10-22 修回日期:2012-10-22 发布日期:2013-02-05
通讯作者: 谢海棠,通信作者,女,研究员,硕士生导师,研究方向:定量药理学,临床药理学。 Tel: 0553-5738350 E-mail: xiehaitang@sina.com
作者简介:徐喆,女,硕士在读,研究方向:临床药理学。 Tel: 15155337370 E-mail: rosexu19880127@sina.com

Meta-analysis: efficacy and safety of asarone on asthmatic bronchitis

XU Zhe¹, CHEN Qun¹, PU Zhi-chen¹, HU Hua¹, XIE Hai-tang^1,2

¹Postgraduate Department,Wannan Medical College,²Clinical Pharmacy Department,Yijishan Hospital of Wannan Medical College,Wuhu 241001,Anhui,China

Received:2012-10-22 Revised:2012-10-22 Published:2013-02-05

摘要/Abstract

摘要： 目的: 评价细辛脑注射液治疗小儿喘息性支气管炎的有效性及安全性。方法: 检索2012年9月以前中国学术期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP)、维普期刊资源整合服务平台、万方数据库、中国生物医学文献数据库(CBM)、PubMed,收集有关细辛脑注射液用于小儿喘息性支气管炎治疗的临床研究进行Meta分析。结果: 纳入文献19篇,Meta分析结果显示,细辛脑组总有效率高于对照组,OR_合并=4.3,95%CI为(3.05,6.08),合并效应量的检验Z=8.3,P<0.01。其他次要结局指标如止咳天数、平喘天数、哮鸣音消失时间、胸片X线恢复正常时间、住院天数等均优于对照组,差异有统计学意义。安全性由于资料有限无法准确评价。结论: 细辛脑注射液能有效治疗小儿喘息性支气管炎,且效果优于对照组。

关键词: 细辛脑注射液, Meta分析, 喘息性支气管炎

Abstract: AIM: To evaluate the efficacy and safety of asarone injection on asthmatic bronchitis. METHODS: The databases were retrieved from CNKI, VIP, CBM, PubMed,Chinese Technologic Journal Database (Weipu) and Wan Fang Digital Journal Full-text Database(before September 2012). The clinical researches about asarone injection in treating asthmatic bronchitis were collected to evaluate the clinical efficacy and safety by meta-analysis.RESULTS: 19 studies were included.The total effective rate of asarone group was higher than that of control group [OR=4.3 and 95%CI =(3.05,6.08),Z=8.3,P<0.00001].And all of other secondary outcome measures of asarone group including cough days, asthma days, wheeze disappeared time, chest X-ray back to normal time, hospital days were better than those of control group, the difference was statistically significant. Safety of asarone injection could not be evaluated because of the information was limited.CONCLUSION: Asarone injection is effective in the treatment of asthmatic bronchitis.

Key words: Asarone injection, Meta-analysis, Asthmatic bronchitis

中图分类号:

R311

徐喆, 陈群, 濮之晨, 胡骅, 谢海棠. 细辛脑注射液治疗小儿喘息性支气管炎临床疗效的Meta分析[J]. 中国临床药理学与治疗学, 2013, 18(1): 39-45.

XU Zhe, CHEN Qun, PU Zhi-chen, HU Hua, XIE Hai-tang. Meta-analysis: efficacy and safety of asarone on asthmatic bronchitis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(1): 39-45.

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