钙非依赖磷脂酶A2与心肌缺血再灌注关系的研究进展

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (11): 1303-1309.

钙非依赖磷脂酶A₂与心肌缺血再灌注关系的研究进展

万星, 石刚刚

汕头大学医学院药理学教研室,汕头 515041,广东

收稿日期:2013-03-16 修回日期:2013-10-22 出版日期:2013-11-26 发布日期:2020-09-17
通讯作者: 石刚刚,男,博士,教授,博士生导师,研究方向:心血管药理及新药开发。Tel: 0754-88566782 E-mail: ggshi@stu.edu.cn
作者简介:万星,女,硕士研究生,研究方向:心血管药理。Tel: 0754-88900432 E-mail: 504810759@qq.com
基金资助:
国家自然科学基金委员会-广东省人民政府联合基金(U0932005)

Research progress on the relationship between calcium-independent phospholipase A₂ and myocardial ischemia/reperfusion

WAN Xing, SHI Gang-gang

Department of Pharmacology, Shantou University Medical College, Shantou 515041, Guangdong, China

Received:2013-03-16 Revised:2013-10-22 Online:2013-11-26 Published:2020-09-17

摘要/Abstract

摘要： 钙非依赖磷脂酶A₂(iPLA₂)是磷脂酶A₂(PLA₂)家族的一大亚族,在信号转导与磷脂重构等方面发挥重要的作用。从1900年研究胰液和蛇毒中的PLA₂开始到现在已过百年,但它在生理过程中的一些重要作用直到近20年才被逐渐认识,而近15年来,越来越多的研究表明,在心肌缺血再灌时,iPLA₂被激活并发挥着重要作用。本文就iPLA₂做一个简介并阐述其与心肌缺血再灌注有关的性质与功能。

关键词: 钙非依赖磷脂酶A₂, 心肌缺血再灌注损伤, 活性调节, 花生四烯酸

Abstract: Calcium-independent phospholipase A₂ (iPLA₂) is a subfamily of phospholipase A₂ (PLA₂), which plays an important role in signal transduction and phospholipid remodeling. Although PLA₂ enzymes were first purified from cobra venom and have been known for over 100 years, only within the last 20 years has their importance in physiologic and pathologic processes been widely recognized. Meanwhile, over the past 15 years, more and more studies have showed that iPLA₂ was activated and played a significant role in myocardial ischemia and reperfusion (I/R). In this review, the functional role of iPLA₂ in I/R is the focus.

Key words: Calcium-independent phospholipase A₂, I/R, Activity control, Arachidonic acid

中图分类号:

万星, 石刚刚. 钙非依赖磷脂酶A₂与心肌缺血再灌注关系的研究进展[J]. 中国临床药理学与治疗学, 2013, 18(11): 1303-1309.

WAN Xing, SHI Gang-gang. Research progress on the relationship between calcium-independent phospholipase A₂ and myocardial ischemia/reperfusion[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(11): 1303-1309.

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钙非依赖磷脂酶A₂与心肌缺血再灌注关系的研究进展

Research progress on the relationship between calcium-independent phospholipase A₂ and myocardial ischemia/reperfusion

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