A2A受体-EETs途径在盐敏感性高血压治疗中的作用

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (12): 1436-1440.

• 综述与讲座 • 上一篇

A₂A受体-EETs途径在盐敏感性高血压治疗中的作用

王琳¹, 吕莉²

¹大连医科大学七年制临床医学院,大连 116044,辽宁;
²大连医科大学药学院,大连 116044,辽宁

收稿日期:2013-03-30 修回日期:2013-11-26 出版日期:2013-12-26 发布日期:2014-01-04
通讯作者: 吕莉,女,硕士,副教授,硕导,主要从事药效学研究。Tel: 13998627321 E-mail: lv_li@126.com
作者简介:王琳,女,临床七年制在读,研究方向:临床医学。Tel: 13840889505 E-mail: wanglinemma@163.com

Effects of the adenosine 2A receptor-epoxyeicosatrienoic acids pathway in the treatment of salt-sensitive hypertension

WANG Lin¹, LU Li²

¹Seven-Year Program of Clinical Medicine, Dalian Medical University, Dalian 116044, Liaoning, China;
²College of Pharmacy, Dalian Medical University, Dalian 116044, Liaoning, China

Received:2013-03-30 Revised:2013-11-26 Online:2013-12-26 Published:2014-01-04

摘要/Abstract

摘要： 激活大鼠腺苷2A受体(A_2AR)可使表氧化酶活性增强,从而提高环氧二十碳三烯酸(EETs)的水平,因EETs有扩张肾血管、降血压等作用,故A_2AR-EETs途径有抗升压作用。通过盐敏感性高血压遗传模型Dahl盐敏感性(Dahl SS)大鼠和Dahl盐抵抗性(Dahl SR)大鼠的相关实验得知,高盐喂养的Dahl SR大鼠,其腺苷水平及肾脏对腺苷的反应性均提高,使其表氧化酶活性和EETs的水平升高,因而引发更加明显的肾血管舒张反应,即Dahl SR大鼠可通过上调A_2AR-EETs途径来调节盐负荷时的血压水平;而Dahl SS大鼠却无上述调节能力。因此在盐负荷时上调Dahl SS大鼠的A_2AR-EETs途径,有利于治疗盐敏感性高血压。

关键词: 腺苷2A受体, 表氧化酶, 环氧二十碳三烯酸, 盐敏感性高血压

Abstract: Activation of rat adenosine 2A receptors (A_2AR) increases epoxygenase activity and epoxyeicosatrienoic acids (EETs) levels. Since EETs have the abilities to dilate the renal vessels and prevent elevation of blood pressure, the adenosine 2A receptor-epoxyeicosatrienoic acids pathway (A_2AR-EETs pathway) is an antipressor. The experiments of the Dahl salt-sensitive (SS) rats and the Dahl salt resistant (SR) rats show that in the Dahl SR rats fed a high salt (HS) diet, elevations of adenosine levels and the renal response to adenosine increase epoxygenase activity and EETs levels, resulting in a greater renal vasodilator. In other words, the Dahl SR rats are able to upregulate the A_2AR-EETs pathway to regulate blood pressure during salt loading. However, the Dahl SS rats don't have the above-mentioned capabilities. Thus upregulating the A_2AR-EETs pathway in the inability of Dahl SS rats during salt loading may contribute to the treatment of salt-sensitive hypertension.

Key words: Adenosine 2A receptors, Epoxygenase, Epoxyeicosatrienoic acids, Salt-sensitive hypertension

中图分类号:

R544.1

王琳, 吕莉. A₂A受体-EETs途径在盐敏感性高血压治疗中的作用[J]. 中国临床药理学与治疗学, 2013, 18(12): 1436-1440.

WANG Lin, LU Li. Effects of the adenosine 2A receptor-epoxyeicosatrienoic acids pathway in the treatment of salt-sensitive hypertension[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(12): 1436-1440.

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A₂A受体-EETs途径在盐敏感性高血压治疗中的作用

Effects of the adenosine 2A receptor-epoxyeicosatrienoic acids pathway in the treatment of salt-sensitive hypertension

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