慢性丙型肝炎患者血清IL-21水平检测及临床意义

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (2): 190-194.

慢性丙型肝炎患者血清IL-21水平检测及临床意义

潘庆春, 余永胜, 汤正好, 奚敏, 臧国庆

上海交通大学附属第六人民医院感染科,上海 200233

收稿日期:2012-10-24 修回日期:2012-10-24 发布日期:2013-02-28
通讯作者: 臧国庆,通信作者,男,主任医师,博导,研究方向:病毒性肝炎的免疫机制研究。 Tel: 021-24058673 E-mail: zangguoqin@126.com
作者简介:潘庆春,男,硕士,研究方向:病毒性肝炎的免疫机制研究。E-mail: pqc992122@126.com
基金资助:
国家自然科学基金 (81077335); 上海市自然科学基金(08ZR1411500)

Serum IL-21 levels in patients with chronic hepatitis C and clinical significance of IL-21

PAN Qing-chun, YU Yong-sheng, TANG Zheng-hao, XI Min, ZANG Guo-qing

Department of Infectious Disease, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China

Received:2012-10-24 Revised:2012-10-24 Published:2013-02-28

摘要/Abstract

摘要： 目的: 检测慢性丙型肝炎(CHC)患者血清白细胞介素21(IL-21)水平及肝功能、HCV-RNA,探讨血清IL-21水平变化与肝功能各项参数及HCV-RNA的关系,研究IL-21在慢性丙型肝炎发病中的作用。方法: 双抗体夹心(ELISA)法检测27例慢性丙型肝炎患者和10例正常对照者血清中IL-21的水平。同时检测患者HCV-RNA、肝功能等指标,并与患者的其他临床数据进行统计分析。结果: 慢性丙型肝炎患者血清IL-21水平显著高于正常对照组(P<0.01);ALT升高的慢性丙型肝炎患者血清IL-21显著高于ALT正常的慢性丙型肝炎患者,且其血清IL-21水平与ALT、AST显著正相关(分别为r=0.647, P<0.01;r=0.591, P<0.01);慢性丙型肝炎患者血清IL-21水平与HCV-RNA水平无显著相关性。结论: IL-21与慢性丙型肝炎肝脏炎症密切相关,是反应慢性丙型肝炎炎症程度的灵敏指标。

关键词: 白细胞介素21, 病毒性肝炎, 丙型, 慢性, 炎症

Abstract: AIM: To determine serum interleukin-21 (IL-21) level and evaluate the roles of IL-21 in chronic hepatitis C (CHC). METHODS: Serum IL-21 levels of 27 CHC patients and 10 control subjects were determined by enzymelinked immunosorbent assay (ELISA) and the relationship between serum IL-21 levels and HCV-RNA, the live biochemical parameters were studied. RESULTS: Serum IL-21 levels in CHC patients were significantly higher than those in control subjects (P<0.01). Especially, CHC patients with elevated alanine aminotransferase (ALT) have higher IL-21 than patients with normal ALT. There were highly significant positive associations between serum IL-21 and ALT (r=0.647, P<0.01) as well as aspartate aminotransferase (AST) (r=0.591, P<0.01). But no association was observed between IL-21 and HCV-RNA. CONCLUSION: IL-21 is a cytokine involved in HCV-associated liver pathological damage and may be an available marker to evaluate hepatic inflammation for CHC.

Key words: IL-21, Chronic hepatitis C, Inflammation

中图分类号:

R512.6⁺3

潘庆春, 余永胜, 汤正好, 奚敏, 臧国庆. 慢性丙型肝炎患者血清IL-21水平检测及临床意义[J]. 中国临床药理学与治疗学, 2013, 18(2): 190-194.

PAN Qing-chun, YU Yong-sheng, TANG Zheng-hao, XI Min, ZANG Guo-qing. Serum IL-21 levels in patients with chronic hepatitis C and clinical significance of IL-21[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(2): 190-194.

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