分子伴侣Tapasin在介导特异性细胞毒性T淋巴细胞反应中的作用

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (2): 212-216.

分子伴侣Tapasin在介导特异性细胞毒性T淋巴细胞反应中的作用

唐余燕, 陈小华, 余永胜

上海交通大学附属第六人民医院感染科, 上海 200233

收稿日期:2012-08-17 修回日期:2012-08-17 发布日期:2013-02-28
通讯作者: 余永胜, 通信作者, 男, 主任医师, 硕导, 研究方向: 病毒性肝炎。E-mail: yuyongsheng@medmail. com. cn
作者简介:唐余燕, 女, 硕士研究生, 研究方向: 病毒性肝炎。 Tel: 13588125004 E-mail: tangyuyan361113248@163. com. cn
基金资助:
国家自然科学基金项目(31000414)

The role of the endoplasmic reticulum chaperone tapasin in mediating specific CTL responses

TANG Yu-yan, CHEN Xiao-hua, YU Yong-sheng

Department of Infectious Diseases, Shanghai Sixth People Hospital, Shanghai Jiao Tong University, Shanghai 200233, China

Received:2012-08-17 Revised:2012-08-17 Published:2013-02-28

摘要/Abstract

摘要： 病毒及肿瘤细胞的清除很大程度上依赖于特异性CD₈⁺细胞毒性T淋巴细胞(CTL), CTL通过T细胞受体(TCR)特异性识别病毒肽段并通过MHC-I类分子提呈引起感染细胞融解,经典MHC-I类分子在内质网内的装配要求有抗原肽配体和β2微球蛋白(β2m)的存在,而这一过程需要伴侣分子(chaperones)如Tapasin的参与。Tapasin是抗原递呈相关转运体(TAP)相关蛋白的基因产物,与MHC-I类分子同为免疫球蛋白超家族成员,在介导特异性CTL反应中有着重要作用,本文简述了Tapasin分子结构特征、在介导特异性CTL反应中的作用及与疾病的联系。

关键词: Tapasin, 细胞毒性T淋巴细胞, MHC-I类分子, 抗原加工

Abstract: The clearing of virus and tumor cell a large degree relied on Specific CD8+ cytotoxic T lymphocytes (cytotoxic T cell, CTL). CTL recognised virus peptide paragraph through T cell receptor (TCR) and caused infection cell melting through MHC-I class molecular presenting. The assembly of classic MHC-I molecular composition in endoplasmic reticulum (ER) required antigen peptide ligand and beta 2m,and this process need chaperones such as tapasin. Tapasin was offspring of transporters associated with antigen processing (TAP) and a member of the immunoglobulin superfamily as well as MHC-I. Tapasin as molecular bridges between TAP and MHC-I, have an important role in mediated specific CTL reactions. This review resumes its biological characteristics, the role in mediated specific CTL reactions and contacting with diseases.

Key words: Tapasin, Cytotoxic T cell, MHC-I, Antigen processing

中图分类号:

R966

唐余燕, 陈小华, 余永胜. 分子伴侣Tapasin在介导特异性细胞毒性T淋巴细胞反应中的作用[J]. 中国临床药理学与治疗学, 2013, 18(2): 212-216.

TANG Yu-yan, CHEN Xiao-hua, YU Yong-sheng. The role of the endoplasmic reticulum chaperone tapasin in mediating specific CTL responses[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(2): 212-216.

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