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中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (5): 586-591.

• 综述与讲座 • 上一篇    下一篇

甲状腺激素的非基因作用与心血管功能

闫晓林, 彭军, 丁启龙   

  1. 中国药科大学药学医学基础实验教学中心,南京 211198,江苏
  • 收稿日期:2012-12-31 修回日期:2013-03-26 出版日期:2013-05-26 发布日期:2013-05-22
  • 通讯作者: 丁启龙,男,副教授,研究方向:内分泌心血管药理。E-mail: dqlcpu@163.com
  • 作者简介:闫晓林,男,硕士研究生,研究方向:内分泌心血管药理。Tel: 15261480597 E-mail: yanlin_31@126.com

Nongenomic actions of thyroid hormone and the cardiovascular function

YAN Xiao-lin, PENG Jun, DING Qi-long   

  1. Experimental and Teaching Center of Medical Basis for Pharmacy, China Pharmaceutical University, Nanjing 211198, Jiangsu, China
  • Received:2012-12-31 Revised:2013-03-26 Online:2013-05-26 Published:2013-05-22

摘要: 甲状腺激素能通过基因作用及非基因作用对机体几乎所有组织产生生理调节作用,通常认为甲状腺激素发挥其生理作用是由核受体调节基因转录介导的,但越来越多的证据表明甲状腺激素亦可与细胞膜、胞浆或线粒体内受体结合触发非基因信号作用,快速调节心血管功能。长期以来甲状腺激素的非基因作用对心血管功能的影响极少有人涉及,本文综述甲状腺激素通过非核受体、第二信使及效应蛋白介导的非基因作用对心血管系统的影响,旨在为心血管疾病的有效治疗和药物开发提供新的途径或靶点。

关键词: 甲状腺激素, 非基因作用, 心血管功能

Abstract: Thyroid hormones play a wide range of important physiological activities in almost all organism. As changes in these hormones levels, observed in hypothyroidism and hyperthyroidism, promote serious derangements of the cardiovascular system, it is important to know their mechanisms of actions. Although the classic genomic actions which are dependent on interaction with nuclear receptors to modulate cardiac myocyte genes expression, there is growing evidence about T3 and T4-triggered nongenomic pathways, resulting from their binding to plasma membrane, cytoplasm, or mitochondrial receptors that leads to a rapid regulation of cardiovascular functions. Disappointedly, little attention is paid to the rapid nongenomic actions of thyroid hormones on cardiovascular system. This paper reviews the effects of thyroid hormones on cardiovascular function via nongenomic actions involving extranuclear receptors, second messengers, or effect proteins. A full understanding of the link between thyroid hormones and cardiovascular functions should be beneficial for appropriate management of cardiovascular diseases by modulating thyroid hormones levels.

Key words: Thyroid hormones, Nongenomic action, Cardiovascular function

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