热毒宁对流感病毒感染致AECOPD患者呼吸困难评分及氧化应激的作用

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (6): 669-673.

热毒宁对流感病毒感染致AECOPD患者呼吸困难评分及氧化应激的作用

卢文宣, 韩伟, 唐华平, 张明泳

青岛大学医学院附属青岛市市立医院东院呼吸科,青岛 266071,山东

收稿日期:2012-12-18 修回日期:2013-05-17 发布日期:2013-06-19
通讯作者: 韩伟,女,博士,副主任医师,研究方向:慢性气道炎症性疾病。Tel: 13335057270 E-mail: sallyhan1@163.com
作者简介:卢文宣,女,硕士在读,研究方向:慢性气道炎症性疾病。Tel: 13173230187 E-mail: wenxuanlu.love@163.com
基金资助:
青岛市公共领域科技支撑计划项目(10-3-3-4-3-nsh)

Effect of Re-Du-Ning on outpatients with acute exacerbation of chronic obstructive pulmonary disease and influenza virus infection

LU Wen-xuan, HAN Wei, TANG Hua-ping, ZHANG Ming-yong

Department of Respiratory Medicine, Qingdao Municipal Hospital(East hospital),Medical College of Qingdao University,Qingdao 266071,Shandong, China

Received:2012-12-18 Revised:2013-05-17 Published:2013-06-19

摘要/Abstract

摘要： 目的: 研究热毒宁对慢性阻塞性肺疾病合并流感病毒感染患者呼吸困难评分及氧化应激水平的作用。方法: 选取可疑病毒感染的慢性阻塞性肺病(COPD)门诊患者320例,用RT-PCR方法检测病人痰液中流感病毒。共检出流感病毒阳性者42例,随机分为热毒宁组(接受热毒宁治疗)和对照组。比较治疗后,两组患者呼吸困难评分[呼吸困难表(MRC)和基础呼吸困难指数(BDI)]、诱导痰中氧化应激因子丙二醛(MDA)、超氧化物歧化酶(SOD)水平及血浆炎症因子(IL-6、IL-8)水平。结果: 治疗后,热毒宁组BDI高于对照组(P<0.05),而两组MRC评分无统计学差异。热毒宁组诱导痰中MDA、SOD 及血浆中IL-8的水平与对照组比较差异均有统计学意义(P<0.05)。结论: 热毒宁通过调节氧化应激水平,改善流感病毒感染的慢性阻塞性肺疾病的呼吸困难情况。

关键词: 慢性阻塞性肺病, 流感病毒, 氧化应激, 热毒宁

Abstract: AIM: To evaluate the effect of Re-Du-Ning on airway oxidative stress and systemic inflammation of acute exacerbation of chronic obstructive pulmonary disease (COPD) with influenza virus infection.METHODS: 320 of COPD out-patients suspected with respiratory virus were enrolled from respiratory clinic successively. Respiratory syndrome, sputum and blood samples had been collected in the first morning after enrolled. After influenza virus in sputum was detected by RT-PCR, the patients with influenza virus were divided into 2 groups: Re-Du-Ning group, who received the treatment of Re-Du-Ning and control group, who received the treatment without Re-Du-Ning and other antioxidants.RESULTS: After treatment, BDI not MRC of Re-Du-Ning group was higher than control group with significant difference (P<0.05). MDA was lower in treatment group than in control group, so as IL-8, and the activity of SOD in treatment group was higher than that in control group (P<0.05).CONCLUSION: Re-Du-Ning improves the respiratory syndrome and systemic inflammation of chronic obstructive pulmonary disease with influenza virus infection via regulating of the imbalance of oxidative stress.

Key words: Chronic obstructive pulmonary disease, Influenza virus, Oxidative stress, Re-Du-Ning

中图分类号:

卢文宣, 韩伟, 唐华平, 张明泳. 热毒宁对流感病毒感染致AECOPD患者呼吸困难评分及氧化应激的作用[J]. 中国临床药理学与治疗学, 2013, 18(6): 669-673.

LU Wen-xuan, HAN Wei, TANG Hua-ping, ZHANG Ming-yong. Effect of Re-Du-Ning on outpatients with acute exacerbation of chronic obstructive pulmonary disease and influenza virus infection[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(6): 669-673.

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