吸入糖皮质激素佐治94例儿童咳嗽变异性哮喘的疗效评估

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (6): 692-695.

吸入糖皮质激素佐治94例儿童咳嗽变异性哮喘的疗效评估

李静杰, 陈旭晨

浙江省奉化市人民医院,奉化 315500,浙江

收稿日期:2012-08-27 修回日期:2012-11-12 发布日期:2013-06-19
作者简介:李静杰,男,本科,主治医师,研究方向:呼吸内科。Tel: 18606875911 E-mail: 5755219@qq.com

Study on clinical efficacy of inhaled corticosteroids in the treatment of 94 children with cough variant asthma

LI Jing-jie, CHEN Xu-chen

Fenghua People's Hospital, Fenghua 315500, Zhejiang, China

Received:2012-08-27 Revised:2012-11-12 Published:2013-06-19

摘要/Abstract

摘要： 目的: 探讨吸入糖皮质激素布地奈德辅助治疗儿童咳嗽变异性哮喘的临床价值。方法: 将2007年3月至2011年3月就诊的94例咳嗽变异性哮喘患儿随机分成两组:对照组47例,采用孟鲁司特片+沙丁胺醇气雾剂治疗;实验组47例,采用孟鲁司特片+沙丁胺醇气雾剂+布地奈德干粉吸入剂治疗。观察比较两组患儿的临床症状缓解时间、治疗后临床效果以及治疗前后肺功能指标。结果: 实验组咳嗽缓解时间与咳嗽消失时间均短于对照组(P<0.05);实验组的临床疗效显著性优于对照组(P<0.05);实验组治疗后肺功能指标均显著优于对照组(P<0.05)。结论: 吸入糖皮质激素布地奈德辅助治疗咳嗽变异性哮喘的临床疗效显著。

关键词: 咳嗽变异型哮喘, 吸入糖皮质激素, 布地奈德干粉吸入剂

Abstract: AIM: To investigate the clinical values about budesonide of inhaled corticosteroids in the treatment of children with cough variant asthma.METHODS: The 94 cases of cough variant asthma children admitted to hospital from March 2007 to March 2011 were randomly divided into two groups, control group (n=47) and treatment group (n=47). The control group was treated with montelukast tablets and salbutamol aerosol, but the treatment group was also given budesonide dry powder inhaler. The clinical effects, the scores of asthma symptom, the time of cough symptom disappeared, and the level of lung function in 2 groups was observed and compared.RESULTS: The total effective rate in the treatment group was significantly higher than the control group (P<0.05); the symptom scores in the treatment group was significantly lower than the control group (P<0.05); the time of cough symptoms disappeared in the treatment group was significantly shorter than the control group (P<0.05); the index value of lung function in the treatment group were significantly better than the control group (P<0.05).CONCLUSION: There is a significant clinical efficacy about budesonide of inhaled corticosteroids for the treatment of children with cough variant asthma.

Key words: Cough variant asthma, Inhaled corticosteroids, Budesonide dry powder inhaler

中图分类号:

R562.2⁺5

李静杰, 陈旭晨. 吸入糖皮质激素佐治94例儿童咳嗽变异性哮喘的疗效评估[J]. 中国临床药理学与治疗学, 2013, 18(6): 692-695.

LI Jing-jie, CHEN Xu-chen. Study on clinical efficacy of inhaled corticosteroids in the treatment of 94 children with cough variant asthma[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(6): 692-695.