多发性骨髓瘤骨病发病机制的研究及治疗进展

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (6): 705-709.

多发性骨髓瘤骨病发病机制的研究及治疗进展

洪娟¹, 汪兴洪²

¹皖南医学院,
²皖南医学院弋矶山医院血液内科, 芜湖 241000,安徽

收稿日期:2012-09-03 修回日期:2013-05-20 发布日期:2013-06-19
通讯作者: 汪兴洪,男,本科,研究方向:血液恶性疾病发病机制。Tel: 13956153809 E-mail: yjSwangxinghong@163.com
作者简介:洪娟,女,硕士,研究方向:血液恶性疾病发病机制。Tel: 18226706655 E-mail: hongjuan419@126.com

Pathogenesis and treatment of the bone disease of multiple myeloma

HONG Juan¹, WANG Xin-hong²

¹Wangnan Medical College,
² Hematology Department of the Affiliated Yijishan Hospital of Wangnan Medical College, Wuhu 241000, Anhui, China

Received:2012-09-03 Revised:2013-05-20 Published:2013-06-19

摘要/Abstract

摘要： 多发性骨髓瘤(Multiple myeloma,MM)是恶性克隆性浆细胞疾病,骨髓瘤骨病(Myeloma bone disease,MBD)是其重要的临床表现之一。其发病机理与骨吸收增加及骨生成减少有关,对骨髓瘤骨病病理机制的研究促进了新的靶向性药物研发。现就目前已知参与MBD发病机制及治疗新进展作一综述。

关键词: 多发性骨髓瘤骨病, 破骨细胞, 成骨细胞, 治疗进展

Abstract: Multiple myeloma is a plasma cell malignancy and bone disease is one of the important clinical features.The mechanisms include the increase of bone resorption and the decrease of bone formation.The progress in acknowledge of the pathophysiology of myeloma bone disease leads to the development of new targeted drugs. This article summarizes the progression of the pathogenesis and treatment of multiple myeloma bone disease.

Key words: Multip lemyeloma bone disease, Osteoclast, Osteoblast, Treatment Progress

中图分类号:

R733.3

洪娟, 汪兴洪. 多发性骨髓瘤骨病发病机制的研究及治疗进展[J]. 中国临床药理学与治疗学, 2013, 18(6): 705-709.

HONG Juan, WANG Xin-hong. Pathogenesis and treatment of the bone disease of multiple myeloma[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(6): 705-709.

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