连续性血液净化治疗对全身炎症反应综合征及脓毒血症患者一氧化氮合酶和降钙素原的影响

中国临床药理学与治疗学 ›› 2014, Vol. 19 ›› Issue (1): 62-66.

连续性血液净化治疗对全身炎症反应综合征及脓毒血症患者一氧化氮合酶和降钙素原的影响

曾爱英¹, 戴木森¹, 王晓萍¹, 陈本敦¹, 陈敏¹, 陈炳星¹, 孙红²

¹福建医科大学省立临床学院福建省立医院急诊内科,福州 350001,福建;
²福建医科大学省立临床学院福建省立医院药剂科,福州 350001,福建

收稿日期:2013-05-24 修回日期:2014-01-08 出版日期:2014-01-27 发布日期:2014-02-12
作者简介:曾爱英,女,硕士,研究方向:急危重症医学。Tel: 13705070130 E-mail: zay2003@126.com
基金资助:
福建省卫生厅青年科研基金(2010-1-1)

Effect of CRRT on nitric oxide synthase and procalcitonin in systemic inflammatory response syndrome and sepsis patients

ZENG Ai-ying¹, DAI Mu-sen¹, WANG Xiao-ping¹, CHEN Beng-dun¹, CHEN Min¹, CHEN Bing-xing¹, SUN Hong²

¹Fujian Provincial Hospital Emergency Medical Department, Provincial Clinical College of Fujian Medical University, Fuzhou 350001, Fujian, China;
²Fujian Provincial Hospital Pharmacy Department, Provincial Clinical College of Fujian Medical University, Fuzhou 350001, Fujian, China

Received:2013-05-24 Revised:2014-01-08 Online:2014-01-27 Published:2014-02-12

摘要/Abstract

摘要： 目的: 研究连续性血液净化(CRRT)对治疗全身炎症反应综合征(SIRS)及脓毒血症(Sepsis)的临床疗效及对患者一氧化氮合酶(NOS)和降钙素原(PCT)的影响,为CRRT和SIRS治疗提供新思路。方法: 收集收住本院急诊ICU、内科ICU及外科ICU的SIRS及Sepsis患者病例,记录在血液净化治疗前及治疗后24、48、72 h 的生命体征、氧合指数(PaO₂/FiO₂)、血生化、血常规、血气分析、APACHE II评分的变化, 并采用比色法检测患者血清NOS含量变化,采用免疫发光法检测患者血清PCT含量变化。结果: 经过CRRT治疗后24、48、72 h 血生化及血常规指标均有显著改善,各时间点NOS值及PCT值较治疗前均显著降低,差异具有统计学意义(P<0.05)。结论: CRRT治疗能显著改善SIRS/Sepsis患者的临床症状,其治疗作用与清除损伤性作用因子NOS及PCT相关。

关键词: 连续性血液净化, 一氧化氮合酶, 降钙素原, 全身炎症反应综合征, 脓毒血症

Abstract: AIM: The purpose of this study is to evaluate the efficacy of the Continuous Renal Replacement Therapy (CRRT) on systemic inflammatory response syndrome (SIRS) and Sepsis and the influence on nitric oxide synthase (NOS) and procalcitonin (PCT), to provide new ideas on the CRRT of SIRS.METHODS: We collected the SIRS and Sepsis cases in Department of emergency ICU, internal medicine ICU and surgical ICU of our hospital, recorded changes (before CRRT, 12, 48, 72 h purification treatment), in vital signs, oxygenation index (PaO₂/FiO₂), blood biochemistry, blood routine, blood gas analysis and APACHE II score. NOS was detected by colorimetric method, and PCT was detected by immune chemiluminescence method.RESULTS: After 24, 48, 72 h of CRRT treatment, blood biochemical and blood indexes were significantly improved, and the values of NOS and PCT were all significantly lower than the values of treatment before. The difference was statistically significant (P<0.05).CONCLUSION: CRRT can improve the clinical symptoms of patients with SIRS/Sepsis by removing the damage factor of NOS and PCT.

Key words: CRRT, NOS, Procalcitonin, SIRS, Sepsi

中图分类号:

R631

曾爱英, 戴木森, 王晓萍, 陈本敦, 陈敏, 陈炳星, 孙红. 连续性血液净化治疗对全身炎症反应综合征及脓毒血症患者一氧化氮合酶和降钙素原的影响[J]. 中国临床药理学与治疗学, 2014, 19(1): 62-66.

ZENG Ai-ying, DAI Mu-sen, WANG Xiao-ping, CHEN Beng-dun, CHEN Min, CHEN Bing-xing, SUN Hong. Effect of CRRT on nitric oxide synthase and procalcitonin in systemic inflammatory response syndrome and sepsis patients[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(1): 62-66.

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