妊娠期乳腺癌诊治药物对胎儿的影响

摘要/Abstract

摘要： 乳腺癌是女性最常见的恶性肿瘤。我国妊娠期乳腺癌约占全部乳腺癌的 1.5%～8.2%,≤35岁育龄期乳腺癌患者约占5%～20%。妊娠期乳腺癌不及时诊治,病情进展甚至会危及生命;但乳腺癌的诊断治疗药物对胎儿健康会产生影响。本文综述了显像造影剂、放射性同位素、前哨淋巴结示踪剂、手术麻醉药物、细胞毒化疗药物、内分泌治疗药物、靶向和其他生物治疗药物等对妊娠期乳腺癌胎儿的影响,以期望肿瘤科、妇科、儿科医师在妊娠期乳腺癌诊断治疗药物对胎儿影响的问题有更深入的了解,能更好地指导医护人员处理、解答乳腺癌在妊娠、哺乳等临床方面实际问题。

关键词: 妊娠, 乳腺癌, 胎儿, 毒副作用

Abstract: Breast cancer is the most common malignant tumor for women. In China, breast cancer during pregnancy accounts for about 1.5%-8.2% of all breast cancer,≤35 years old fertile period breast cancer accounts for about 5%-20%. Breast cancer during pregnancy does not make a diagnosis and give treatment in time, illness will progress and even life-threatening; But the diagnosis and treatment of breast cancer drugs will be affect fetal health. Imaging contrast agents, radioactive isotope, sentinel lymph node tracer, anesthesia drugs, cytotoxic chemotherapy, endocrine therapy, targeted and other biological treatment for breast cancer during pregnancy was reviewed in this paper.Hope oncology department, gynecology, pediatrics physicians in the diagnosis and treatment of breast cancer drug effects on the fetus during pregnancy have a better understanding on the matter.To better solve the clinical actual problems such as breast cancer during pregnancy and lactation,to better guide the medical personnel processing.

Key words: pregnancy, breast cancer, the fetus, side effects

中图分类号:

杜向慧, 季永领, 王晓稼. 妊娠期乳腺癌诊治药物对胎儿的影响[J]. 中国临床药理学与治疗学, 2014, 19(2): 206-213.

DU Xiang-hui, JI Yong-lin, WANG Xiao-jia. The influence of the drug on the fetus of diagnosis and treatment of breast cancer during pregnancy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(2): 206-213.

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