盆炎坤和汤对苯酚胶浆致慢性盆腔炎大鼠模型的影响

中国临床药理学与治疗学 ›› 2014, Vol. 19 ›› Issue (4): 381-384.

盆炎坤和汤对苯酚胶浆致慢性盆腔炎大鼠模型的影响

李钦¹, 李晓丽², 赵吟¹, 张萍青², 张信岳¹

¹浙江省医学科学院药物研究所药理室,杭州 310013,浙江;
²浙江省中医院中医妇科,杭州 310006,浙江

收稿日期:2013-08-24 修回日期:2014-03-14 出版日期:2014-04-26 发布日期:2020-07-24
通讯作者: 张信岳,通信作者,男,研究员,硕导,研究方向:中药药理。Tel:0571-88215600 E-mail:zhangxy2003@aliyun.com
作者简介:李钦,女,硕士,助理研究员,研究方向:中药药理。Tel:0571-88215600 E-mail:qindai_1981@sohu.com
基金资助:
浙江省医学重点学科群建设项目(XKQ-010-001)

Studies on the changes of chronic pelvic inflammatory disease(CPID) rat model of Penyankunhe liquor

LI Qin¹, LI Xiao-li², ZHAO Yin¹, ZHANG Ping-qing², ZHANG Xin-yue¹

¹Department of Pharmacology, Zhejiang Academy of Medical Sciences, Hangzhou 310013, Zhejiang, China;
²Department of Gynecology Zhejiang Provincial Hospital of TCM, Hangzhou 310006, Zhejiang, China

Received:2013-08-24 Revised:2014-03-14 Online:2014-04-26 Published:2020-07-24

摘要/Abstract

摘要： 目的: 观察盆炎坤和汤对苯酚胶浆致慢性盆腔炎大鼠模型的影响。方法: 雌性SD大鼠,子宫内注射苯酚胶浆造成大鼠慢性盆腔炎模型,造模2周后分组,并灌胃给予盆炎坤和汤高、中、低3个剂量(66、33、16.5 g/kg),连续 14 d,观察大鼠体质量、子宫脏体比、子宫内膜的病理组织学改变,检测血清中超氧化物歧化酶(SOD)、丙二醛(MDA)的含量。结果: 造模后大鼠体质量明显降低,子宫脏体比明显增加,血清SOD水平显著下降,MDA含量明显升高,盆炎坤和汤各剂量用药后对上述指标改变均有程度不同的对抗作用,病理检查结果也表明盆炎坤和汤各剂量对子宫内膜炎症程度有一定的改善作用。结论: 盆炎坤和汤对苯酚胶浆致慢性盆腔炎大鼠模型有一定的治疗作用。

关键词: 盆炎坤和汤, 慢性盆腔炎, 苯酚胶浆

Abstract: AIM: To investigate the changes of Penyankunhe liquor on the CPID rat model. METHODS: The model was established with injection of phenol mucilage.Two weeks later the rats were randomly divided into Penyankunhe liquor low dose group,medium dose group and high dose group(66,33,16.5 g/kg).After the rats were treated 14 days with corresponding medicine intragastric administration, the rats body weight, the ratio value of the rats womb were observed,the pathological of endometrium was used to evaluate the effects of Penyankunhe liquor.The cotent of SOD and MDA in serum were also detected. RESULTS: The rats body weight was decreased and the ratio value of the rats womb was increased significantly,and the levels of SOD in serum were reducted while the MDA content was increased significantly.It was also found that each dose of Penyankunhe liquor had different digrees of protection against the indicators change.The pathologic examination results also showed that the Penyankunhe liquor had certain improvement effect on the degree of endometrial inflammation. CONCLUSION: Penyankunhe liquor is effective in treating CPID in experimental rats.

Key words: Penyankunhe liquor, chronic pelvic inflammatory disease(CPID), phenol mucilage

中图分类号:

R965.2

李钦, 李晓丽, 赵吟, 张萍青, 张信岳. 盆炎坤和汤对苯酚胶浆致慢性盆腔炎大鼠模型的影响[J]. 中国临床药理学与治疗学, 2014, 19(4): 381-384.

LI Qin, LI Xiao-li, ZHAO Yin, ZHANG Ping-qing, ZHANG Xin-yue. Studies on the changes of chronic pelvic inflammatory disease(CPID) rat model of Penyankunhe liquor[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(4): 381-384.

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