重楼生化汤预防剖宫产术后恶露不绝的临床研究

中国临床药理学与治疗学 ›› 2014, Vol. 19 ›› Issue (4): 437-441.

重楼生化汤预防剖宫产术后恶露不绝的临床研究

江延姣¹, 黄益平¹, 叶慧君¹, 应鸣²

¹浙江中医药大学附属第二医院妇产科,
²超声科,杭州 310005,浙江

收稿日期:2013-08-03 修回日期:2014-04-18 出版日期:2014-04-26 发布日期:2020-07-24
通讯作者: 叶慧君,通信作者,女,学士,主任医师,研究方向:妇科肿瘤及内分泌。Tel:0571-85288322 E-mail:yehuihui1213@126.com
作者简介:江延姣,女,硕士,主治医师,讲师,研究方向:围产医学及妇科内分泌。Tel:13185719869 E-mail:jiangyanjiao0518@aliyun.com
基金资助:
浙江省中医药管理局科研项目(2012ZB068);浙江中医药大学校级科研项目(2011ZY15)

Study of Chonglou Shenghua Tang on preventing lochiorrhagia after caesarean section

JIANG Yan-jiao¹, HUANG Yi-ping¹, YE Hui-jun¹, YING Ming²

¹Department of Gynaecology and Obstetrics,
²Department of Ultrasonography, the Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang, China

Received:2013-08-03 Revised:2014-04-18 Online:2014-04-26 Published:2020-07-24

摘要/Abstract

摘要： 目的: 探讨重楼生化汤预防剖宫产术后恶露不绝的有效性和安全性。方法: 采用随机单盲研究法,选择2011年1月至2013年1月在浙江中医药大学附属第二医院住院行子宫下段剖宫产产妇584例为研究对象。其中试验组(重楼生化汤组)198例,于术后 6 h 起予重楼生化汤 100 mL,2次/d,连服 14 d;对照1组(经典生化汤组)198例,术后 6 h 起予经典生化汤 100 mL,2次/d,连服 14 d;安慰剂组188例,术后6 h起予安慰剂 100 mL,2次/d,连服 14 d。观察:(1)子宫复旧:住院期间宫底高度,术后 42 d B超监测子宫三径之和、宫腔积血、子宫切口愈合;(2)恶露:血性恶露的量及持续时间、恶露持续时间;(3):术后肛门排气时间,服药期间不良反应。结果: (1)子宫复旧:宫底高度:术后第2天至第5天宫子底高度及平均宫底下降速度,各组间均有显著差异,重楼生化汤组显著优于经典生化汤组及安慰剂组(P均＜0.05)。术后 42 d B超测量子宫三径之和三组间比较均有统计学差异,重楼生化汤组均显著小于经典生化汤组及安慰剂组(P均＜0.05)。子宫切口I类愈合率,重楼生化汤组显著优于其他两组(P均＜0.05)。(2)恶露:血性恶露量及持续时间,三组间比较均有统计学差异,重楼生化汤组均显著优于经典生化汤组及安慰剂组(P均＜0.05)。(3)术后肛门排气时间及安全性观察:术后重楼生化汤组平均肛门排气时间显著早于对照组(P＜0.05)。用药期间重楼生化汤组4例在服药初期有轻微腹泻。结论: 剖宫产术后应用重楼生化汤可明显预防恶露不绝的发生,且药物安全性较好。

关键词: 重楼生化汤, 剖宫产, 恶露不绝, 子宫复旧

Abstract: AIM: To evaluate the efficacy and safty of Chonglou Shenghua Tang for preventing lochiorrhagia after caesarean section (CS). METHODS: Using prospective and single blind methods, 584 women underwent caesarean section (CS) were divided into three groups randomly : Chonglou Shenghua Tang group(198 cases), Classical Shenghua Tang group (198 cases), placebo group (184 cases),and were administered by Chonglou Shenghua Tang, Classical Shenghua Tang and placebo 100 mL, per 12 hours 14 days after CS respectively. The following clinical parameter were collected and analyzed: (1) Uterine instauration: fundus height, the average drop speed of fundus;the sum of the three paths of uterus and uterine cavity hematocele, uterine incision healing by ultrasound monitoring 42 days after CS; (2)The lochia: the amount and duration of lochia rubra, duration of lochia. (3) The time of anus exhaust, adverse reaction. RESULTS: (1)Uterine instauration: On the height of fundus from the 2nd day to the fifth day after CS and the average drop speed of fundus, there were significant differences between groups, and Chonglou Shenghua Tang group was significantly better than the classical Shenghua Tang group and placebo group (P＜0.05). On the sum of the three paths of uterus, Chonglou Shenghua Tang group was significantly less than the Classical Shenghua Tang group group and placebo group(P＜0.05).Chonglou Shenghua Tang group was significantly better than the other two groups about uterine incision healing rate(P＜0.05). (2) On the amount and duration of lochia rubra, Chonglou Shenghua Tang group was significantly superior to the classical Shenghua Tang group and placebo group(P＜0.05).(3) Chonglou Shenghua Tang group was shorter than the control group significantly on the time of average anal exhaust(P＜0.05).4 cases with mild diarrhea at the beginning with the drug had been observed. CONCLUSION: It is efficacious and safe of using Chonglou Shenghua Tang to prevent lochiorrhagia after caesarean section.

Key words: Chonglou Shenghua Tang, lochiorrhagia, uterine instauration, caesarean section

中图分类号:

R714

江延姣, 黄益平, 叶慧君, 应鸣. 重楼生化汤预防剖宫产术后恶露不绝的临床研究[J]. 中国临床药理学与治疗学, 2014, 19(4): 437-441.

JIANG Yan-jiao, HUANG Yi-ping, YE Hui-jun, YING Ming. Study of Chonglou Shenghua Tang on preventing lochiorrhagia after caesarean section[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(4): 437-441.

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