欢迎访问《中国临床药理学与治疗学》杂志官方网站,今天是

中国临床药理学与治疗学 ›› 2014, Vol. 19 ›› Issue (4): 450-453.

• 药物治疗学 • 上一篇    下一篇

ERCP与EST并发出血的相关临床研究

贾玉良1,2, 姜华2, 韩真2, 邹晓平1   

  1. 1南京大学医学院研究生班,南京 210032,江苏;
    2皖南医学院第一附属医院弋矶山医院消化内科,芜湖 241000,安徽
  • 收稿日期:2013-10-24 修回日期:2014-04-03 出版日期:2014-04-26 发布日期:2020-07-24
  • 通讯作者: 邹晓平,通信作者,男,博士生导师,主任医生、教授,主要研究方向:消化病学,消化内镜。Tel:13770771661 E-mail:zouxiaoping795@hotmail.com
  • 作者简介:贾玉良,男,本科,副主任医师,主要研究方向:消化病学,消化内镜。Tel:13955330270 E-mail:ajia94@hotmail.com
  • 基金资助:
    皖南医学院中青年课题(WK200704F)

Clinical research on the bleeding in ERCP and EST

JIA Yu-liang1,2, JIANG Hua2, HAN Zhen2, ZOU Xiao-ping1   

  1. 1Graduate Student Class of Medical School of Nanjing University, Nanjing 210032, Jiangsu, China;
    2Digestive Department of the First Affiliated Hospital of Wannan Medical College, Wuhu 241000, Anhui, China
  • Received:2013-10-24 Revised:2014-04-03 Online:2014-04-26 Published:2020-07-24

摘要: 目的: 研究胆总管结石经内镜逆行性胰胆管造影术(ERCP)与十二指肠乳头切开术(EST)并发出血的相关危险因素,并探讨有效防治措施。方法: 研究性分析皖南医学院弋矶山医院消化内镜中心2012年1月至2012年12月299例胆总管结石患者行ERCP与EST取石术的临床资料。结果: 299例患者,术中少量出血52例,明显出血50例,成功插入乳头时间经方差分析(F=3.713)差异有统计学意义(P=0.026,P<0.05);出血病例中,存在憩室21例,出血量与憩室的关系经卡方检验(χ2=5.314)差异有统计学意义(P=0.021,P<0.05);术中出血患者分别采用内镜下电凝止血与钛夹止血处理,经Fisher精确概率检验法,提示内镜下钛夹止血治疗的止血有效率高于电凝止血治疗(P=0.044,P<0.05);并发术后出血11例,药物止血6例,4例止血无效,内镜止血5例,均有效止血,经Fisher精确概率检验法,提示内镜下止血有效率高于药物止血(P=0.045,P<0.05)。结论: 胆总管结石ERCP与EST并发出血与成功插入乳头时间,有无憩室等因素相关,内镜下干预治疗是防治术中术后出血的有效措施。

关键词: ERCP, EST, 出血, 内镜

Abstract: AIM: To analyze the concurrent bleeding-related causes and identify effective prevention measures of common bile duct stones by ERCP and EST. METHODS: 299 cases of common bile duct stones underwent ERCP and EST lithotomy clinical data of Digestive Endoscopic Center in Yijishan Hospital of Wannan Medical College from January 2012 to December 2012 were researched and analyzed. RESULTS: The 299 patients,52 cases of less bleeding and 50 cases of significant bleeding in surgery, the difference of the time inserting nipple by analysis of variance (F=3.713) was statistically significant (P=0.026); in the bleeding cases, 21 cases of diverticulum, the difference of the relationship between the amount of bleeding and diverticula by the chi-square test (χ2 =5.314) was statistically significant (P<0.05); the Fisher exact test showed that hemostasis titanium clips under endoscopic was more efficient than electric coagulation therapy (P<0.05); in 11 cases of postoperative bleeding, 6 cases treated by drugs,4 cases were invalid, 4 cases treated by endoscopic hemostasis treatment, all cases were effective, the Fisher exact test showed that the postoperative bleeding under endoscopic was more efficient than therapy of drugs (P<0.05). CONCLUSION: The concurrent bleeding of common bile duct stones by ERCP and EST is related to the time of successfully inserting the nipple, and the exist of diverticulitis, endoscopic hemostasis treatment is the effective measure of preventing and treating bleeding.

Key words: ERCP, EST, bleeding, endoscopic

中图分类号: