与性别因素相关的莫达非尼药动学特征的 Meta 分析

中国临床药理学与治疗学 ›› 2014, Vol. 19 ›› Issue (6): 651-655.

与性别因素相关的莫达非尼药动学特征的 Meta 分析

李亚东, 王天笑, 洪宗元

皖南医学院定量药理研究所, 药理学教研室, 芜湖 241002, 安徽

收稿日期:2014-02-14 修回日期:2014-06-06 发布日期:2014-07-01
通讯作者: 洪宗元, 男, 博士, 教授, 研究方向: 定量药理学及神经药理学。Tel: 0553-3932003 E-mail: zyhongwnmc@aliyun.com
作者简介:李亚东，男，硕士在读，研究方向：神经药理学。Tel:0553-3932003 E-mail:yadlee@126.com.王天笑，共同第一作者，男，硕士在读，研究方向：神经药理学。Tel:0553-3932003 E-mail:wangtianxiao0512@163.com
基金资助:
国家自然科学基金面上项目(81171255);教育部科学技术研究重点项目(208058)

A Meta-analysis of modafinil pharmacokinetics and gender

LI Ya-dong, WANG Tian-xiao, HONG Zong-yuan

Institute of Quantitative Pharmacology, Department of Pharmacology, Wannan Medical College, Wuhu 241002, Anhui, China

Received:2014-02-14 Revised:2014-06-06 Published:2014-07-01

摘要/Abstract

摘要： 目的: 评价莫达非尼在人体内药动学特征是否具有性别差异, 制定合理的临床给药方案。方法: 检索 Pubmed、Medline、Ovid、springer link、CNKI、VIP、CBM 等数据库, 选取自 1994 年 1 月至 2013 年 2 月间发表的有关莫达非尼(单剂量口服给药)在人体内药动学研究方面的文献, 按系统评价方法进行筛选, 用 Revman 5.0 软件对药物消除半衰期(t_1/2β)、曲线下面积(AUC_0-∞)和血药浓度达峰时间(t_max)三个药动学参数进行 Meta 分析。结果: 共纳入 8 篇文献, 含样本 207 例。Meta 分析结果显示, 与男性相比, 女性的t_1/2β明显缩短(均数差为 1.13, 95% CI=0.31~1.96, P=0.007), AUC_0-∞ 则显著增大(均数差为 -6.37, 95% CI = -9.20~-3.53, P<0.0001);而 t_max 无明显性别差异(均数差为 -0.11, 95% CI=-0.32~0.10。P=0.32)。结论: 莫达非尼在人体内的 t_1/2β 与 AUC_0-∞ 等药动学参数存在性别差异, 这为制定合理的临床给药方案提供了药动学参考。

关键词: 莫达非尼, 药动学, Meta 分析, 性别因素

Abstract: AIM : Modafinil is a potent wake-promoting compound with low abuse potential used in the treatment of narcolepsy and day time sleepiness. This paper was to evaluate the difference of modafinil pharmacokinetics between females and males for developing more reasonable clinical dosing regimens.METHODS: A systematic review and Meta-analysis of pharmacokinetic studies that administered a single oral dose of modafinil were performed. Pharmacokinetic parameters of modafinil were from 8 papers selected from Pubmed, Medline, Ovid, springer link, CNKI, VIP and CBM etc. databases for January of 1994 to February of 2013. The three pharmacokinetics parameters:t_1/2β, AUC_0-∞, Tmax were analysised using Revman 5.0 software.RESULTS:Pooled analysis (n=207) demonstrated that the elimination half-life (t_1/2β) of modafinil in females was shorter than that in males (Mean difference =1.13, 95% CI=0.31-1.96, P=0.007), while the area under the concentration-time curve (AUC_0-∞) in females was increased significantly, compared with that in males (Mean difference =-6.37, 95% CI =- 9.20--3.53, P<0.0001). However, the peak plasma modafinil concentration (t_max) was no difference between females and males (Mean difference=-0.11, 95% CI=-0.32-0.10, P=0.32).CONCLUSION: This study indicates a marked effect of gender factor on modafinil pharmacokinetics, which provides a reference for reasonable administration in clinic.

Key words: modafinil, pharmacokinetics, meta analysis, gender factor

中图分类号:

R969.2

李亚东, 王天笑, 洪宗元. 与性别因素相关的莫达非尼药动学特征的 Meta 分析[J]. 中国临床药理学与治疗学, 2014, 19(6): 651-655.

LI Ya-dong, WANG Tian-xiao, HONG Zong-yuan. A Meta-analysis of modafinil pharmacokinetics and gender[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(6): 651-655.

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