布比卡因腰麻剖宫产术中舒芬太尼的半数有效剂量

中国临床药理学与治疗学 ›› 2014, Vol. 19 ›› Issue (6): 663-665.

布比卡因腰麻剖宫产术中舒芬太尼的半数有效剂量

项小兵¹, 方军¹, 金孝岠², 柳兆芳²

¹浙江省肿瘤医院麻醉科, 杭州 310022, 浙江;
²皖南医学院附属弋矶山医院麻醉科, 芜湖 241001, 安徽

收稿日期:2013-09-23 修回日期:2014-05-13 发布日期:2014-07-01
通讯作者: 柳兆芳, 女, 主任医师, 研究方向:临床麻醉与药理。E-mail: liuzhaofan@163.com
作者简介:项小兵, 男, 硕士, 主治医师, 研究方向:临床麻醉与药理。E-mail: 237607488@qq.com

ED₅₀ of sufentanil combined with bupivacaine for spinal anesthesia in cesarean section

XIANG Xiao-bing¹, FANG Jun¹, JIN Xiao-ju², LIU Zhao-fang²

¹Department of Anesthesiology, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang, China;
²Department of Anesthesiology, Yijishan Hospital, Wannan Medical College, Wuhu 241001, Anhui, China

Received:2013-09-23 Revised:2014-05-13 Published:2014-07-01

摘要/Abstract

摘要： 目的: 采用序贯法测定腰麻剖宫产术舒芬太尼的半数有效剂量(ED₅₀)。方法: 40例剖宫产患者, 选择L3/4间隙穿刺, 药物为布比卡因、舒芬太尼的等比重混合液, 其中布比卡因固定为 7.5 mg, 初始舒芬太尼剂量为 1.2 μg, 按等比 1.2 倍的阶梯增减给药, 若麻醉平面维持在T6达1 h表示成功, 则下一例患者梯减一级剂量, 反之, 下一例患者梯增一级剂量。采用Dixon-Massey计算ED₅₀。结果: 21例患者麻醉成功, 舒芬太尼的半数有效剂量是 0.84 μg, 95%可信区间是 0.78～0.90 μg。结论: 腰麻剖宫产术中布比卡因 7.5 mg 复合舒芬太尼的半数有效剂量是 0.84 μg。

关键词: 舒芬太尼, 布比卡因, 麻醉, 蛛网膜下腔, 剂量效应关系, 序贯

Abstract: AIM : To study the minimal effective dose of sufentanil spinal anesthesia in cesarean section.METHODS: Forty patients undergoing cesarean section were enrolled in this study and L3/4 was chosen for lumbar puncture.The solution used for spinal anesthesia was sufentanil and bupivacaine, in which the dose of bupivacaine was fixed 7.5 mg. While the initial dose of sufentanil was 1.2 μg, according to 1.2 times increase or decrease the administration. If the level of spinal anesthesia reached to T6 and up to 1 hour, the dose decreased 1 grade for next patient. On the contrary, the dose increased 1 grade in the next one. The ED₅₀ of sufentanil was calculated by Dixon-Massey sequential method.RESULTS:Twenty-one patients had the good effect of spinal anesthesia. The ED₅₀ of sufentanil for cesarean section was 0.84 μg, and its 95% confidence interval was 0.78-0.90 μg.CONCLUSION: The minimal effective dose of sufentanil combined with bupivacaine 7.5 mg for spinal anesthesia in cesarean section was 0.84 μg.

Key words: sufentail, bupivacaine, anesthesia, spinal, dose-response relationship, sequential

中图分类号:

R614

项小兵, 方军, 金孝岠, 柳兆芳. 布比卡因腰麻剖宫产术中舒芬太尼的半数有效剂量[J]. 中国临床药理学与治疗学, 2014, 19(6): 663-665.

XIANG Xiao-bing, FANG Jun, JIN Xiao-ju, LIU Zhao-fang. ED₅₀ of sufentanil combined with bupivacaine for spinal anesthesia in cesarean section[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(6): 663-665.

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