白藜芦醇逆转肿瘤多药耐药的研究进展

摘要/Abstract

摘要： 肿瘤的多药耐药是导致化疗失败的主要原因, 克服耐药是目前癌症研究面临的主要困难之一, 研究耐药产生的相关机制和寻找有效的逆转剂逐渐成为肿瘤研究的热点。本文结合国内外文献, 对白藜芦醇(resveratrol, Rev)逆转多药耐药及其可能的作用机制等作一概述。

关键词: 白藜芦醇, 多药耐药, P-gp

Abstract: One of the greatest obstacles to effective chemotherapy is the development of drug resistance. Overcoming drug resistance is one of the main challenges of current cancer research. Molecular mechanisms of drug resistance and to find effective reversal agents have become the hot spot in tumor research. This review summarizes the probable mechanism of the resveratrol's inhibition action on MDR.

Key words: resveratrol, multidrug resistance, P-gp

中图分类号:

R969

王子元, 程卓安, 殷佩浩. 白藜芦醇逆转肿瘤多药耐药的研究进展[J]. 中国临床药理学与治疗学, 2014, 19(6): 717-720.

WANG Zi-yuan, CHENG Zhuo-an, YIN Pei-hao. Research advance in resveratrol's inhibition action on multidrug resistance[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(6): 717-720.

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