119例重症药疹的回顾性分析

中国临床药理学与治疗学 ›› 2014, Vol. 19 ›› Issue (8): 885-889.

119例重症药疹的回顾性分析

汪琳^{1, 2}, 邱晓燕²

¹ 复旦大学附属华山医院药剂科,上海 200040;
² 皖南医学院弋矶山医院药剂科,芜湖 241001,安徽

收稿日期:2013-05-09 修回日期:2014-05-09 出版日期:2014-08-26 发布日期:2014-08-26
通讯作者: 邱晓燕,女,博士,副主任药师,研究方向:临床药学。 Tel: 021-52888712 E-mail: xyqiu@163.com
作者简介:汪琳,女,硕士研究生,主管药师,研究方向:临床药学。 Tel: 0553-5739177 E-mail: wanglin0553@126.com

Retrospective analysis of 119 cases with severe drug eruption

WANG Lin^{1, 2}, QIU Xiao-yan²

¹ Department of Pharmacy,Huashan Hospital of Fudan University,Shanghai 200040, China;
² Department of Pharmacy Yijishan Hospital,Wannan Medical College,Wuhu 241001, Anhui, China

Received:2013-05-09 Revised:2014-05-09 Online:2014-08-26 Published:2014-08-26

摘要/Abstract

摘要： 目的探讨重症药疹的临床特点、常见致敏药物及治疗,为临床安全用药,减少重症药疹发生提供参考。方法对华山医院2006年1月-2012年12月收治的119例重症药疹患者的临床资料进行回顾性分析。结果致敏药物类别以抗菌药物最多见(43例,30.1%),最易引起重症药疹的两种药物为卡马西平(32例,26.9%)和别嘌呤醇(23例,19.3%);药疹类型中,重症多形性红斑型为最常见的重症药疹;中毒性表皮坏死松解型为最凶险的类型,死亡2例,死因均为呼吸衰竭。结论对易致重症药疹的药物临床使用中应加强药学监护,发现异常及时停药,并早期、足量使用糖皮质激素,控制并发症的发生。

关键词: 重症药疹, 重症多形性红斑, 中毒性表皮坏死松解型, 药物超敏反应综合征, 药品不良反应

Abstract: AIM: To investigate the common sensitize medicines and prevention of severe drug eruption and appreciate causal link between the drug and the reaction. METHODS: A retrospective study over a period of 7 years (January 2006 to December 2012) was carried out in the hospital to record severe cutaneous ADRs of 119 hospitalized patients.RESULTS: Antibacterials were the most common causative drugs(43,30.1%).Carbamazepine(32,26.9%) and allopurinol(23,19.3%) were the commonest initiating drugs.SJS accounted for the highest proportion,TEN accounted for the most dangerous.Two cases died of respiratory failure.CONCLUSION: Prone to cause severe drug eruption drug, strengthening pharmaceutical care during clinical use. abnormal timely withdrawal and giving sufficient corticosteroids treatment early to control the incidence of complications.

Key words: severe drug eruption, steven-johnson syndrome, toxic epidermal necrolysis, drug induced hypersensitivity syndrome, adverse drug reaction

中图分类号:

汪琳, 邱晓燕. 119例重症药疹的回顾性分析[J]. 中国临床药理学与治疗学, 2014, 19(8): 885-889.

WANG Lin, QIU Xiao-yan. Retrospective analysis of 119 cases with severe drug eruption[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(8): 885-889.

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