雷替曲塞或5-氟尿嘧啶联合奥沙利铂一线治疗晚期胃癌的对比性研究

中国临床药理学与治疗学 ›› 2015, Vol. 20 ›› Issue (2): 194-198.

雷替曲塞或5-氟尿嘧啶联合奥沙利铂一线治疗晚期胃癌的对比性研究

何杨, 彭玉珍, 吉兆宁

皖南医学院弋矶山医院肿瘤内科,芜湖 241000 ,安徽

收稿日期:2014-05-21 修回日期:2015-02-14 出版日期:2015-02-26 发布日期:2015-03-20
通讯作者: 吉兆宁,男,主任医师、教授,硕士生导师,研究方向:恶性肿瘤治疗的药理学研究。Tel: 0553-5739060 E-mail: jzning@163.com
作者简介:何杨,女,硕士,主治医师、讲师,研究方向:恶性肿瘤的化学与生物治疗。Tel: 0553-5739060 E-mail: heyang418@sina.com
基金资助:
皖南医学院中青年科研基金项目(WK2013F01)

Clinical study of oxaliplatin plus raltitrexed versus oxaliplatin plus fluorouracil as first-line treatment for advanced gastric cancer

HE Yang, PENG Yu-zhen, JI Zhao-ning

Department of Medical Oncology,Yijishan Hospital,Wannan Medical colleg, Wuhu 241001,Anhui ,China

Received:2014-05-21 Revised:2015-02-14 Online:2015-02-26 Published:2015-03-20

摘要/Abstract

摘要： 目的: 观察雷替曲塞联合奥沙利铂(A组)与5-氟尿嘧啶联合奥沙利铂(B组)一线治疗晚期胃癌的近期疗效和毒副反应。方法: 晚期胃癌43例,具体用法:A组(21例):雷替曲塞 3 mg/m² 静滴,第1 天;奥沙利铂 130 mg/m² 静滴,第1 天。B组(22例):亚叶酸钙 200 mg/m² 静滴,第1~5天;氟尿嘧啶 375 mg/m² 静滴,第1~5 天;奥沙利铂 130 mg/m² 静滴,第1 天。两方案均3 周为1 周期。每3 个周期评价疗效,直至疾病进展或毒副反应不能耐受,最多化疗6 周期。结果: 两组的有效率(RR)分别为 47.6%和 31.8%(P=0.289),A组中位无进展生存期(PFS)9.8个月,明显优于B组的 6.6 个月,两组对比差异有统计学意义(χ²=3.928,P=0.047)。两组方案的恶心呕吐及手足综合征反应差异具有统计学意义(P＜0.05),余毒副反应发生率近似。结论: 与5-氟尿嘧啶联合奥沙利铂(B组)方案相比,雷替曲塞联合奥沙利铂(A组)方案一线治疗晚期胃癌可延长患者的无进展生存期(PFS),且耐受性较好。

关键词: 雷替曲塞, 5-氟尿嘧啶, 奥沙利铂, 胃癌

Abstract: AIM: Department of Medical Oncology,Yijishan Hospital,Wannan Medical colleg, Wuhu 241001,Anhui ,ChinaMETHODS: A total of 43 patients with advanced gastric cancer were divided into two groups, 21 cases in Group A:raltitrexed 3 mg/m² ivgtt;d1;oxaliplatin 130 mg/m² ivgtt,d1. 22 cases in Group B:leucovorin 200 mg/m² ivgtt,d1-d5; fluorouracil 375 mg /m² ivgtt,d1-d5; oxaliplatin 130 mg/m² ivgtt,d1. The two regimens were 21days as a cycle,and a total of six cycles was applied unless there was an evidence of disease progression or intolerance of treatment.The efficacy was evaluated after 3-cycle chemotherapy.RESULTS: In Group A and Group B,RR were 47.6% and 31.8% respectively(P=0.289),PFS were 9.8 and 6.6 months respectively(P=0.047). There were differences with the side-effects between the two groups on nausea,sickness and hand-foot syndrome(P＜0.05).Other toxicities were similar.CONCLUSION: Compared with the treatment of oxaliplatin plus fluorouracil,oxaliplatin plus raltitrexed as first-line treatment for advanced gastric cancer has a longer PFS,and the toxicity is well tolerated.

Key words: raltitrexed, 5-flurouracil, oxaliplation, gastric cancer

中图分类号:

何杨, 彭玉珍, 吉兆宁. 雷替曲塞或5-氟尿嘧啶联合奥沙利铂一线治疗晚期胃癌的对比性研究[J]. 中国临床药理学与治疗学, 2015, 20(2): 194-198.

HE Yang, PENG Yu-zhen, JI Zhao-ning. Clinical study of oxaliplatin plus raltitrexed versus oxaliplatin plus fluorouracil as first-line treatment for advanced gastric cancer[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(2): 194-198.

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