人源型抗C5单克隆抗体Eculizumab的应用

摘要/Abstract

摘要： 补体系统是获得性免疫系统的重要部分,补体在多种疾病的病理生理过程中发挥着主要作用。阵发性睡眠性血红蛋白尿症(PNH)是一种获得性造血干细胞基因突变所致的难治性溶血性疾病。人源型抗补体蛋白C5单克隆抗体(Eculizumab)是于2007年被美国FDA和欧盟委员会唯一认可的定向治疗PNH的药物。本文将对其在PNH及其他补体相关疾病的治疗中的应用进行综述。

关键词: 单克隆抗体, Eculizumab, 阵发性睡眠性血红蛋白尿症

Abstract: The complement system is an important part of the innate immune system. Complement plays a crucial role in the pathophysiology of many disorders. Paroxysmal nocturnal hemoglobinuria (PNH) is a refractory hemolytic disease caused by acquired hematopoietic stem cell gene mutation. Eculizumab is a humanized monoclonal antibody that inhibits complement factor C5. It was approved as the only recognition of directional drug for the treatment of PNH by the US FDA and the European Commission in 2007. In this article, the applications of Eculizumab in treating PNH and other complement related diseases in recent years will be reviewed.

Key words: monoclonal antibody, Eculizumab, paroxysmal nocturnal hemoglobinuria (PNH)

中图分类号:

R552

王艳, 吕莉. 人源型抗C5单克隆抗体Eculizumab的应用[J]. 中国临床药理学与治疗学, 2015, 20(4): 455-459.

WANG Yan, LV Li. Applications of Eculizumab, a humanized anti-complement factor C5 monoclonal antibody[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(4): 455-459.

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