冰片在药代动力学方面的研究进展

摘要/Abstract

摘要： 近些年来,对于冰片的自身性质及其对其他药物的体内行为的影响相关研究比较多。因此,有必要对近年来冰片的研究做系统地归纳。本文综述了冰片自身及其促进其它药物吸收、分布、代谢及排泄等药代动力学方面的进展。结果显示,冰片能改变血脑屏障、眼角膜、皮肤及其他黏膜的结构,促进其他药物透过这些结构到达作用部位。但对冰片体内代谢的研究尚显不足,在冰片是原型成分排出还是以转化为樟脑排出问题上存在分歧。较为严重的问题是,很多研究忽略了冰片的成分因品种而异的特点,使各种研究成果之间无法互相参考,甚至出现矛盾。这些问题均亟待解决。

关键词: 冰片, 眼角膜, 血脑屏障, 鼻黏膜

Abstract: In recent years, the research for their own properties of borneol and its impact on the rest of the drug in vivo is more. Therefore, it is necessary to summarize the research of borneol in recent years. This paper reviews the progress of borneol and promote other drug on absorption, distribution, metabolism and excretion of pharmacokinetic aspects. The results showed that the borneol can change the blood brain barrier (BBB) ,cornea, skin and other mucous membrane structure, and to promote other drugs through these structures to reach the site of action. But the study of metabolism of borneol is still inadequate,in synthetic borneol is vented or prototype components to be converted into camphor discharge are divided on the issue. More serious problem is that a lot of research ignores the composition owing to the different varieties of characteristics of borneol, making it is impossible to refer to each other, and even inconsistencies between the various research results. These problems are to be solved.

Key words: borneol, cornea, blood-brain barrier, nasal mucosa

中图分类号:

R969

滕毅, 杨海玲. 冰片在药代动力学方面的研究进展[J]. 中国临床药理学与治疗学, 2015, 20(4): 469-475.

TENG Yi, YANG Hai-ling. Research progress on the pharmacokinetic profile of borneol[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(4): 469-475.

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