银杏达莫注射液联合高压氧和针灸治疗突发性耳聋的临床疗效和安全性

摘要/Abstract

摘要：

目的: 本研究旨在探讨银杏达莫注射液联合高压氧和针灸治疗突发性耳聋的临床疗效和安全性，为其临床治疗提供参考。方法: 将94例突发性耳聋患者按照随机数字表法分为对照组（47例）和观察组（47例），两组患者均给予西医常规治疗，对照组采用高压氧联合针灸治疗，观察组在对照组治疗基础上给予20 mL银杏达莫注射液静脉滴注。2周后观察临床疗效和安全性，比较血液流变学指标、凝血功能、过氧化脂质 (LPO)、超氧化物歧化酶 (SOD)、血栓素B2 (TXB2)及血管内皮细胞钙黏蛋白 (VE-cadherin)水平。结果: 观察组总有效率为98.87%，对照组总有效率为82.98%，秩和检验差异无统计学意义（P>0.05）。观察组纯音听阈值低于对照组，差异有统计学意义（P<0.05）。观察组患者的血浆黏度、全血黏度、红细胞压积及红细胞聚集指数均明显低于对照组，差异均有统计学意义（P<0.05）。观察组凝血酶时间高于对照组，而纤维蛋白原、凝血因子Ⅰ和血小板因子水平低于对照组，差异均有统计学意义（P<0.05）。观察组LPO、TXB2及VE-cadherin水平低于对照组，而SOD水平高于对照组，差异有统计学意义（P<0.05）。两组患者的不良反应主要为头痛、胃肠道不适、心慌、皮肤瘙痒，观察组和对照组的药物不良反应发生率分别为21.28%和17.02%，差异无统计学意义（P>0.05）。结论: 银杏达莫注射液联合高压氧和针灸治疗突发性耳聋具有较好的临床疗效，能降低纯音听阈值恢复听力，改善血液流变学指标和凝血功能，修复血管损伤内皮，且安全性较好，值得临床推广应用。

关键词: 突发性耳聋, 银杏达莫, 高压氧, 针灸, 血液流变学, 凝血功能

Abstract:

AIM: To explore the curative effect and security of ginkgo-dipyridamolum injection combined hyperbaric oxygen and acupuncture in treatment of patients with sudden deafness, and to provide a reference for clinical treatment. METHODS: Ninety-four patients with sudden deafness were divided into the control group (47 cases) and observation group (47 cases) according to random number table method. The two groups were given conventional western medicine treatment, the control group was given hyperbaric oxygen and acupuncture, while the observation group was given 20 mL ginkgo-dipyridamolum injection by intravenous drip on the basis of control group treatment. After 2 weeks treatment the clinical curative effect and safety were observed, and the blood rheology indexes, coagulation function, lipid peroxide (LPO) superoxide dismutase (SOD), thromboxane B2 (TXB2) and vascular endothelial cadherin (VE-cadherin) were compared. RESULTS:The total effective rate was 98.87% in the observing group, and 82.98% in the control group, there was no statistically significant difference of rank and inspection (P>0.05). The pure tone hearing threshold value in the observation group was lower than the control group, the difference was statistically significant (P<0.05). The whole blood viscosity, plasma viscosity, erythrocyte deposited and erythrocyte aggregation index in the observation group were significantly lower than the control group, the differences were statistically significant (P<0.05). The thrombin time in the observation group was higher than the control group, and the fibrinogen, blood coagulation factor Ⅰ and platelet factor were lower than the control group, the differences were statistically significant (P<0.05). The levels LPO, TXB2 and VE-cadherin of the observation group were lower than the control group, and the SOD level was higher than that in the control group, the differences were statistically significant (P<0.05). The mainly adverse reactions were headache, gastrointestinal discomfort, palpitation, itchy skin in two groups. The incidences of adverse drug reactions were 21.28% and 17.02% in the observation group and control group,respectively.There was no statistically significant difference (P>0.05). CONCLUSION:Ginkgo-dipyridamolum injection combined hyperbaric oxygen and acupuncture in treatment of patients with sudden deafness have better clinical curative effect, can reduce the pure tone hearing threshold value to restore hearing, improve blood rheology indexes and blood coagulation function, repair blood vessels endothelial injury, and have better security. They are worthy of clinical popularization and application.

Key words: sudden deafness, ginkgo-dipyridamolum, hyperbaric oxygen, acupuncture, blood rheology, blood coagulation function

中图分类号:

R764.43+

张琼敏李斯斯张杰朱翌. 银杏达莫注射液联合高压氧和针灸治疗突发性耳聋的临床疗效和安全性[J]. 中国临床药理学与治疗学, 2017, 22(6): 668-673.

ZHANG Qiongmin, LI Sisi, ZHANG Jie, ZHU Li. Curative effect and security of ginkgo-dipyridamolum injection combined hyperbaric oxygen and acupuncture in treatment of patients with sudden deafness[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(6): 668-673.

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