白三烯B4、颈动脉斑块性质与进展性缺血性脑卒中相关性

中国临床药理学与治疗学 ›› 2017, Vol. 22 ›› Issue (6): 689-693.

白三烯B4、颈动脉斑块性质与进展性缺血性脑卒中相关性

马红岗，潘琴妹，朱斐斐，王亚仙，王庄

湖州市中心医院神经内科，湖州 313000，浙江

收稿日期:2016-11-22 修回日期:2017-02-24 出版日期:2017-06-26 发布日期:2017-06-26
作者简介:马红岗，男，硕士，副主任医师，研究方向：脑血管疾病。 Tel：13819201201 E-mail：13819201201@163.com
基金资助:
湖州市科学技术局项目（2014GYB36）

Relationship between leukotriene B4，carotid plaque and progressive ischemic stroke

MA Honggang，PAN Qinmei，ZHU Feifei，WANG Yaxian，WANG Zhuang

Neurology Department of Huzhou Center Hospital, Huzhou 313000, Zhejiang, China

Received:2016-11-22 Revised:2017-02-24 Online:2017-06-26 Published:2017-06-26

摘要/Abstract

摘要：

目的: 探讨白三烯B4(leukotriene B4，LTB4)、颈动脉斑块性质与进展性缺血性脑卒中相关性。方法: 选取2014年1月至2016年1月于本院接受治疗的80例进展性缺血性脑卒中为进展组，按照随机数表法选择同期入院治疗的80例非进展性的缺血性脑卒中患者为非进展组，同时选取同期入院非脑卒中患者80例为对照组。对三组患者入院不同时间点血清LTB4进行检测记录，并对组间、组内进行比较，对具有统计学差异的指标行多因素Logistic回归分析，研究进展性缺血性脑卒中的相关风险因素。结果: 进展组在入院时及入院后不同时间点LTB4水平均高于非进展组及对照组（P<0.05）。在颈动脉硬化亚组中，进展组中不稳定斑块所占比率明显高于非进展组和对照组（P<0.05），且不稳定斑块组LTB4水平均高于稳定斑块组和无斑块组（P<0.05）。在进展组中，中重度进展组在入院时、入院第3天、入院第7天LTB4表达水平较轻度进展组高（P<0.05）。非条件Logistic回归分析显示异常升高的血清LTB4水平和颈动脉不稳定斑块与进展性脑卒中的发生发展存在相关性（P<0.05）。结论: LTB4、颈动脉斑块能够影响进展性缺血性脑卒中的发生和发展，是进展性缺血性脑卒中的危险因素，临床上LTB4浓度及颈动脉不稳定斑块可作为进展性缺血性脑卒中早期预测指标。

关键词: 白三烯B4, 动脉粥样斑块, 进展性缺血性脑卒中

Abstract:

AIM: To study the relationship between leukotriene B4, carotid plaque and progressive ischemic stroke. METHODS: Eighty patients with progressive ischemic stroke treated in our hospital from January 2014 to January 2016 were enrolled in this study as the progress group. Eighty non-progressive ischemic patients were selected according to the random number table as the non-progress group. Another 80 cases of non-stroke patients were selected as the control group. Level of leukotriene B4 at different stages were detected and compared between and within the three groups. Indicators with statistical significance were analyzed with logistic regression analysis to investigate the risk factors associated with progressive ischemic stroke. RESULTS: The level of LTB4 in the progress group was higher than that in the non-progress group and the control group at admission time and after admission (P<0.05). In the carotid atherosclerosis subgroup, the percentage of unstable plaques in the progress group was significantly higher than that in the non-progress group and the control group (P<0.05), and the LTB4 level in the unstable plaque group was higher than that in the stable plaque group (P<0.05). In the progress group, LTB4 expression was significantly higher in the moderate to severe progression group than that in the mild progression group at admission, hospitalization day 3 and hospitalization day 7 (P<0.05). Unconditional logistic regression analysis showed that abnormal serum LTB4 levels and unstable carotid plaques were associated with the progressive stroke (P<0.05). CONCLUSION: Carotid plaques can affect the development of progressive ischemic stroke, which is a risk factor for progressive ischemic stroke, and leukotriene B4 concentration and unstable carotid artery plaque maybe early predictors of ischemic stroke.

Key words: leukotriene B4, atherosclerotic plaques, progressive ischemic stroke

中图分类号:

R743.3

马红岗，潘琴妹，朱斐斐，王亚仙，王庄. 白三烯B4、颈动脉斑块性质与进展性缺血性脑卒中相关性[J]. 中国临床药理学与治疗学, 2017, 22(6): 689-693.

MA Honggang，PAN Qinmei，ZHU Feifei，WANG Yaxian，WANG Zhuang. Relationship between leukotriene B4，carotid plaque and progressive ischemic stroke[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(6): 689-693.

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