醒脑静注射液对脑梗死缺氧诱导因子-1α表达的影响

中国临床药理学与治疗学 ›› 2017, Vol. 22 ›› Issue (7): 821-824.

醒脑静注射液对脑梗死缺氧诱导因子-1α表达的影响

陈雁斌¹，邓珊珊²

¹湘南学院附属医院神经内科，郴州 423000，湖南；²南华大学附属第二医院内分泌科，衡阳 421001，湖南

收稿日期:2016-12-22 修回日期:2017-03-27 出版日期:2017-07-26 发布日期:2017-07-19
通讯作者: 邓珊珊，女，硕士，主治医师，主要从事糖尿病与心脑血管疾病风险等的研究。 Tel:18674766690 E-mail:14014535@qq.com

Effect of Xingnaojing injection on the expression of hypoxia-inducible factor-1α in patients with acute cerebral infarction

CHEN Yanbin¹, DENG Shanshan ²

¹Department of Neurology, Affiliated Hospital of XiangNan University, Chenzhou 423043, Hunan, China; ²Department of Endocrinology, the Second Affiliated Hospital of University of South China, Hengyang 421001, Hunan, China

Received:2016-12-22 Revised:2017-03-27 Online:2017-07-26 Published:2017-07-19
About author:陈雁斌，男，本科，主治医师，主要从事脑血管疾病的研究。 Tel:13507359299 E-mail:chenyanbin-cz@163.com

摘要/Abstract

摘要：

目的: 观察醒脑静注射液对脑梗死患者的疗效及对缺氧诱导因子-1α(hypoxia-inducible factor-1α，HIF-lα)水平的影响。方法: 68例脑梗死患者随机分为治疗组35例和对照组33例，对照组给予常规治疗，治疗组在对照组治疗的基础上给予醒脑静注射液，疗程均为10 d。治疗前，治疗后3 d、10 d分别进行神经功能缺损评分（NIHSS）及检测血清HIF-lα水平。结果: 治疗后3 d、10 d，治疗组的NIHSS评分较治疗前下降，差异具有统计学意义（P<0.05）；与对照组比较，治疗组下降更明显，两组差异具有统计学意义（P<0.05）。治疗后3 d、10 d两组血清HIF-lα水平均较治疗前下降，差异具有统计学意义（P<0.05）；与治疗组比较，对照组下降更明显，两组差异具有统计学意义（P<0.05）。Pearson相关分析显示HIF-lα水平与NIHSS减少值呈正相关（P<0.05）。结论: 醒脑静注射液可通过上调血清HIF-lα表达水平保护、治疗缺血脑组织。

关键词: 醒脑静注射液, 脑梗死, 缺氧诱导因子-1α

Abstract:

AIM: To investigate the effect of Xingnaojing injection on ischemic stroke patients and its impact on the level of hypoxia-inducible factor-1α(HIF-lα). METHODS: Sixty-eight cases of ischemic stroke patients were randomly divided into treatment group (n=35) and control group (n=33). Both groups were given regular treatment for 10 days. Patients of treatment group were given additional Xingnaojing injection. Evaluation of National Institutes of Health Stroke Scale (NIHSS) score and detection of serum HIF-lα level were performed before treatment, 3 days and 10 days after the treatment. RESULTS: After treatment, NIHSS scores of treatment group on day 3 and day 10 and those of control group on day 10 were statistically lower than those before treatment（P<0.05), the treatment group decreased more significantly (P<0.05). Serum HIF-lα level of both groups on day 3 and day 10 were statistically lower as compared to those before treatment（P<0.05）, the control group decreased more significantly（P<0.05）. Pearson correlation analysis showed that the level of HIF-lα was positively correlated with the decreasing of NIHSS(P<0.05). CONCLUSION: Xingnaojing injection can protect and improve ischemic brain tissues by promoting serum HIF-lα level.

Key words: Xingnaojing injection, ischemic stroke, hypoxia-inducible factor-1α

中图分类号:

R743.3

陈雁斌，邓珊珊. 醒脑静注射液对脑梗死缺氧诱导因子-1α表达的影响[J]. 中国临床药理学与治疗学, 2017, 22(7): 821-824.

CHEN Yanbin, DENG Shanshan. Effect of Xingnaojing injection on the expression of hypoxia-inducible factor-1α in patients with acute cerebral infarction[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(7): 821-824.

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