加味增液汤对复方地芬诺酯诱导的便秘小鼠的影响

中国临床药理学与治疗学 ›› 2017, Vol. 22 ›› Issue (8): 866-869.

加味增液汤对复方地芬诺酯诱导的便秘小鼠的影响

赵天文，汤晗霄，黄文静，鲍逸舒，陈聪聪，陈东生，盛云杰，张永生

浙江中医药大学，杭州 310053，浙江

收稿日期:2017-01-16 修回日期:2017-06-20 出版日期:2017-08-26 发布日期:2017-08-18
通讯作者: 张永生，男，博士，副研究员，研究方向：抗肝纤维化研究。 Tel：0571-86613763E-mail：alex.yszhang@zcmu.edu.cn
作者简介:赵天文，男，硕士研究生，研究方向：抗肝纤维化研究。 Tel：15968844822 E-mail：ztwn623144@163.com
基金资助:
浙江省中药现代化产业技术创新联盟项目（2010LM304）；浙江省自然科学基金（LY16H280004）；国家自然科学基金（81573700）

Effects of Jiawei Zengye decoction on diphenoxylate-induced constipation in mice

ZHAO Tianwen, TANG Hanxiao, HUANG Wenjing, BAO Yishu, CHEN Congcong, CHEN Dongsheng, SHENG Yunjie, ZHANG Yongsheng

Zhejiang Medical University, Hangzhou 310053, Zhejiang, China

Received:2017-01-16 Revised:2017-06-20 Online:2017-08-26 Published:2017-08-18

摘要/Abstract

摘要：

目的: 考察在增液汤（包括玄参、生地、麦冬）基础上增加铁皮石斛和/或生白术对复方地芬诺酯诱导的便秘小鼠的影响。方法: 采用复方地芬诺酯建立小鼠便秘模型，制备增液汤+生白术+铁皮石斛、生白术+增液汤、增液汤水煎液及麻仁胶囊溶解液，分别灌胃给药后检测便秘小鼠排便、小肠推进情况及血清超氧化物歧化酶（SOD）活力。结果: 增液汤+生白术+铁皮石斛与生白术+增液汤促进排便及小肠推进的疗效优于增液汤及麻仁胶囊溶解液；增液汤+生白术+铁皮石斛可显著提高便秘小鼠血清SOD活力，优于增液汤及麻仁胶囊溶解液。结论: 生白术（或生白术+铁皮石斛）可增强增液汤对复方地芬诺酯诱导的小鼠便秘的疗效，铁皮石斛+生白术+增液汤可提高便秘小鼠血清SOD活力。

关键词: 铁皮石斛, 增液汤, 便秘, 胃肠运动

Abstract:

AIM: To study the effect of dendrobii officmalis caulis (DOC) and/or atractylodismacrocephalaerhizoma (AMR) based on Zengyedecoction (ZYD), including scrophulariaeradix, rehmanniaeradix, ophiopogonisradix on diphenoxylate-induced constipation in mice. METHODS: Diphenoxylate was used to establish the mouse model of constipation, the decoction of DOC+AMR+ZYD, AMR+ZYD and ZYD, the dissolving liquid of Maren capsule (MRC) were prepared, after the gavage administration of them respectively, the defecation, small intestine propulsion and serum SOD activity in constipated mice were detected.RESULTS:The efficacy of promoting defecation and small intestine propulsion by DOC+AMR+ZYD and AMR+ZYD was better than that of ZYD and MRC; DOC+AMR+ZYD significantly increased serum SOD activity in constipated mice and the efficacywas superior to ZYD and MRC. CONCLUSION:DOC+AMR and AMR enhanced ZYD efficacy on diphenoxylate-induced constipation in mice,DOC+AMR+ZYD elevated the constipated mice serum SOD activity.

Key words: dendrobii officmalis caulis, Zengyedecoction, constipation, gastrointestinal motility

中图分类号:

R965.2

赵天文，汤晗霄，黄文静，鲍逸舒，陈聪聪，陈东生，盛云杰，张永生. 加味增液汤对复方地芬诺酯诱导的便秘小鼠的影响[J]. 中国临床药理学与治疗学, 2017, 22(8): 866-869.

ZHAO Tianwen, TANG Hanxiao, HUANG Wenjing, BAO Yishu, CHEN Congcong, CHEN Dongsheng, SHENG Yunjie, ZHANG Yongsheng. Effects of Jiawei Zengye decoction on diphenoxylate-induced constipation in mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(8): 866-869.

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