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中国临床药理学与治疗学 ›› 2017, Vol. 22 ›› Issue (9): 1050-1055.

• 药物治疗学 • 上一篇    下一篇

基于三联疗法治疗幽门螺杆菌相关复发性口腔溃疡56例

范美君,王金龄,马 锴,孔秀玲   

  1. 三亚市人民医院口腔科,三亚 572000,海南
  • 收稿日期:2017-04-11 修回日期:2017-04-26 出版日期:2017-09-26 发布日期:2017-09-30
  • 基金资助:

    海南省医药卫生科研项目(15A200051)

Treatment for 56 cases of recurrent oral ulcer associated with helicobacter pylori based on riple therapy

FAN Meijun, WANG Jinling, MA Kai, KONG Xiuling   

  1. Department of Stomatology, the People's Hospital of Sanya, Sanya 572000, Hainan, China
  • Received:2017-04-11 Revised:2017-04-26 Online:2017-09-26 Published:2017-09-30
  • About author:范美君,女,本科,主治医师,研究方向:复发性口腔溃疡的防治研究。 Tel:18907611116 E-mail:fanmeijunkqk@126.com

摘要:

目的: 基于三联疗法治疗幽门螺杆菌(helicobacter pylori,HP)相关复发性口腔溃疡(recurrent oral ulcer,ROU)56例,为预防和治疗ROU患者提供新的借鉴及思路,以期提高临床疗效。方法: 选取HP相关ROU患者100例作为研究对象,按随机数字表法分为观察组56例和对照组44例。观察组采用三联疗法联合康复新液含漱治疗,对照组采用康复新液含漱治疗,均予连续治疗7 d。对比两组临床疗效、疼痛指数、超敏C-反应蛋白、溃疡面愈合时间、不良反应和治愈患者6个月内 HP根除率及复发率。结果: 治疗结束时,观察组治愈率和总有效率分别为91.07%和100%,分别与对照组65.91%和86.36%比较,差异均有统计学意义(P<0.01)。其次,两组疼痛指数和超敏C-反应蛋白较治疗前,差异有统计学意义(P<0.01),且观察组优于或显著性优于对照组,差异存在统计学意义(P<0.05或0.01)。再者,观察组溃疡面愈合时间较对照组,差异有统计学意义(P<0.05)。另外,两组均未发生与试验药物治疗相关死亡,肝肾功能检验正常,其不良反应主要表现为轻微的口干、恶心、纳差,差异并无统计学意义(P>0.05),且患者无需停药就能耐受。最后,观察组治愈患者6个月内HP根除率和复发率较对照组,差异均有统计学意义(P<0.01)。结论: 复发性口腔溃疡与HP相关,采用康复新液治疗HP相关ROU,佐以三联疗法,可收到显著的疗效,且有效改善症状和体征,并提高HP清除率和降低复发率,不良反应轻微、可耐受,建议临床治疗应用。

关键词: 三联疗法, 幽门螺杆菌, 复发性口腔溃疡, 康复新液, 临床观察

Abstract:

AIM: To study the treatment for 56 cases recurrent oral ulcer (ROU) associated with helicobacter pylori (HP) based on the triple therapy so as to provide a new reference and idea for prevention and treatment of ROU patients in hope of improving the clinical curative effect.  METHODS: One-hundred cases of ROU associated with HP were selected and randomly divided into observation group (56 cases) and control group (44 cases). The observation group was administered with the triple therapy combined with Kangfuxin liquid. While the control group was given single Kangfuxin liquid. Both groups received 7 d continuous treatment. The clinical curative effect, pain index, HS-CRP, ulcer healing time, adverse drug reaction, recurrence rate and eradication rate of HP within six months of two groups were compared. RESULTS: At the end of treatment, the cure rate of the observation group was 91.07% and total effective rate was 100%, and those of the control group were 65.91% and 86.36%, respectively. The differences were statistically significant (P<0.01). Compared with before treatment, pain index and HS-CRP of the two groups showed significant difference after treatment (P<0.01); and the observation group showed more significant difference than that of control group (P<0.05 or 0.01). Compared with the control group, ulcer surface healing time of the observation group showed significant difference (P<0.05). The two groups presented no drug-related death. And liver and kidney function were tested normal. The main adverse reactions were slightly dry mouth, nausea and poor appetite which showed no statistically significant difference (P>0.05), and patients tolerated the reaction without drug withdrawal. Comparison of eradication rate of HP and recurrence rate within six months was statistically significant (P<0.01). CONCLUSION: ROU is associated with HP; Kangfuxin liquid combined with the triple therapy to treat HP associated with ROU are effective, which can improve the symptoms and the HP removing rate, and reduce recurrence rate with no adverse reaction. It is referential for clinical application.

Key words: triple therapy, helicobacter pylori, recurrent oral ulcer, Kangfuxin liquid, clinical observation

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