临床药学服务对幽门螺杆菌阳性消化性溃疡患者用药依从性及治疗效果的影响分析

doi:10.12092/j.issn.1009-2501.2018.02.016

中国临床药理学与治疗学 ›› 2018, Vol. 23 ›› Issue (2): 199-204.doi: 10.12092/j.issn.1009-2501.2018.02.016

临床药学服务对幽门螺杆菌阳性消化性溃疡患者用药依从性及治疗效果的影响分析

李静静¹，虞燕霞¹，唐莲¹，张金坤²，余强²，尚尔宁¹

¹南京医科大学附属苏州医院药学部，²消化内科，苏州 215002，江苏

收稿日期:2017-07-31 修回日期:2017-08-22 出版日期:2018-02-26 发布日期:2018-03-02
通讯作者: 尚尔宁，女，本科，主任药师，研究方向：医院药学。 Tel: 0512-62362321 E-mail: slyyyjk2006@sina.com
作者简介:李静静，女，硕士，药师，研究方向：临床药学。 Tel: 0512-62362325 E-mail: lijingno.2@163.com
基金资助:
江苏省药学会-奥赛康医院药学科研项目（201408）

Influence of clinical pharmaceutical care on medication compliance and treatment effect in Helicobacter pylori positive peptic ulcer outpatients

LI Jingjing¹, YU Yanxia ¹, TANG Lian¹, ZHANG Jinkun², YU Qiang², SHANG Erning¹

¹Department of Pharmacy, ²Department of Gastroenterology, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou 215002, Jiangsu, China

Received:2017-07-31 Revised:2017-08-22 Online:2018-02-26 Published:2018-03-02

摘要/Abstract

摘要：

目的: 评价临床药学服务对幽门螺杆菌（H.pylori）阳性消化性溃疡患者用药依从性及治疗效果的影响。方法: 前瞻性纳入2015年7月-2016年6月我院消化内科门诊H.pylori阳性消化性溃疡患者96名，随机分为对照组和干预组，对照组予常规门诊服务，干预组予用药教育及随访。分别于根除H.pylori治疗前后对患者用药依从性、胃肠道症状进行评分，抗酸治疗结束至少4周后14C尿素呼气试验复查H.pylori根除率。结果: 临床药学服务干预组患者用药依从性评分显著高于对照组（3.73 vs. 2.58,P<0.01），提高程度具有显著性差异（1.71 vs. 0.44，P<0.01），干预组患者的完全服药率为81.25%，对照组为60.42%，差异有统计学意义（P<0.05）；干预组胃肠道症状改善44人，对照组36人（91.67% vs. 75.00%，P<0.05）；HP根除率干预组显著高于对照组（91.67% vs. 72.92%，P<0.05）。结论: 临床药学服务能显著提高门诊消化性溃疡患者根除H.pylori治疗的用药依从性和H.pylori根除率，并改善患者胃肠道症状。

关键词: 临床药学服务, 根除幽门螺杆菌, 消化性溃疡, 用药依从性

Abstract:

AIM: To assess the influence of clinical pharmaceutical care on medication compliance and treatment effect in Helicobacter pylori (H.pylori) eradication in outpatients with peptic ulcer. METHODS: Ninety-six outpatients with H.pylori positive peptic ulcer from July 2015 to June 2016 were prospectively collected and were randomly divided into control group and intervention group. Patients in the control group were given the traditional outpatient service. The intervention group patients received pharmaceutical education and follow-up by clinical pharmacist. Medication compliance and gastrointestinal symptom were assessed in both groups before and after H.pylori eradication therapy. H.pylori eradication rates of all patients were tested by 14C urea breath test after the end of stopping all medicines for at least 4 weeks. RESULTS: The score and the improvement of compliance with medication of intervention group patients were significantly higher than those of the control group (3.73 vs.2.58, 1.71 vs.0.44, P<0.01). 81.25% of patients in intervention group and 60.42% of patients in control group took all prescribed doses. The difference was statistically different（P<0.05）. Forty-four patients of the intervention group and thirty-six patients in the control group reported less gastrointestinal symptoms (91.67% vs.75.00%, P<0.05). The H.pylori eradication rate of the intervention group was significantly higher than that of the control group (91.67% vs.72.92%, P<0.05). CONCLUSION: Clinical pharmaceutical care has a significant effect on H.pylori eradication rate, medication compliance and the improvement of gastrointestinal symptom.

Key words: clinical pharmaceutical care, Helicobacter pylori eradication, peptic ulcer, medication compliance

中图分类号:

R969.3

李静静，虞燕霞，唐莲，张金坤，余强，尚尔宁. 临床药学服务对幽门螺杆菌阳性消化性溃疡患者用药依从性及治疗效果的影响分析[J]. 中国临床药理学与治疗学, 2018, 23(2): 199-204.

LI Jingjing, YU Yanxia, TANG Lian, ZHANG Jinkun, YU Qiang, SHANG Erning. Influence of clinical pharmaceutical care on medication compliance and treatment effect in Helicobacter pylori positive peptic ulcer outpatients[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(2): 199-204.

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临床药学服务对幽门螺杆菌阳性消化性溃疡患者用药依从性及治疗效果的影响分析

Influence of clinical pharmaceutical care on medication compliance and treatment effect in Helicobacter pylori positive peptic ulcer outpatients

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