关键词: 丁丙诺啡, 小儿, 全麻下腹腔镜疝气修补术, 镇痛作用

Abstract:

AIM: To investigate the analgesia effect of small amount of buprenorphine on children undergoing laparoscopic hernia repair under general anesthesia. METHODS: From January 2016 to June 2017, sixty-two children undergoing laparoscopic hernia operation under general anesthesia in our hospital were randomly divided into control group and study group, with 31 cases in each group. The study group received buprenorphine 3 μg/kg on the induction of anesthesia, and the control group received equal amount of saline. Inflammatory cytokines, immune function were detected at Pre infusion (T₀), postoperative 6 h (T₁), 12 h (T₂), and 24 h (T₃), and pain and sedation scores as well as the clinical index and agitation classification were observed and compared after the operation. RESULTS: Compared with T₀, levels of serum CRP, TNF-α and Cor in the control group increased at T₁, T₂, and T₃; levels of CD₄⁺, CD₈⁺, CD₄⁺/CD₈⁺ decreased; levels of serum CRP, TNF-α and Cor in the study group increased at T₂, and T₃; levels of CD₄⁺, CD₈⁺,CD₄⁺/CD₈⁺ decreased (P＜0.05). Compared with the control group, levels of serum CRP, TNF-α and Cor in the study group at T₁, T₂, and T₃ were lower; levels of CD₄⁺, CD₈⁺, CD₄⁺/CD₈⁺ were higher (P＜0.05). Compared with T₁, RASS scores in the control group decreased at T₂ and T₃; pain scores and RASS scores in the study group decreased at T₂, T₃. Compared with the control group, pain scores and RASS scores in the study group at T₂, T₃ were lower (P＜0.05), the cough response and agitation scores in the study group were lower than those of the control group (P＜0.05). CONCLUSION: Small amount of buprenorphine has a good analgesic and sedative effects on pediatric laparoscopic hernia repair under general anesthesia by reducing inflammation and improving immune function.

Key words: buprenorphine, children, pediatric laparoscopic hernia repair under general anesthesia, abirritation