曲美他嗪对稳定型心绞痛患者血清同型半胱氨酸及谷氨酰转肽酶含量的影响

doi:10.12092/j.issn.1009-2501.2018.08.014

中国临床药理学与治疗学 ›› 2018, Vol. 23 ›› Issue (8): 922-926.doi: 10.12092/j.issn.1009-2501.2018.08.014

曲美他嗪对稳定型心绞痛患者血清同型半胱氨酸及谷氨酰转肽酶含量的影响

盛洋，张田杰

浙江省立同德医院心血管内科，杭州 310012，浙江

收稿日期:2018-04-04 修回日期:2018-07-04 出版日期:2018-08-26 发布日期:2018-08-28
作者简介:盛洋，男，硕士，主治医师，研究方向：心内科常见病多发病的西医及中西医结合的诊治。 Tel：13968099159 E-mail：Shengyang1234@sina.com
基金资助:
浙江省医学会临床科研基金项目（2015ZYC-A09）

Effects of trimetazidine on serum-homocysteine and serum-gamma-glutamyl transferase level in the cases of stable angina cordis

SHENG Yang, ZHANG Tianjie

Department of Cardiology, Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang, China

Received:2018-04-04 Revised:2018-07-04 Online:2018-08-26 Published:2018-08-28

摘要/Abstract

摘要：

目的: 探讨曲美他嗪对冠心病患者血清同型半胱氨酸及谷氨酰转肽酶含量的影响。方法: 选择稳定型心绞痛患者80例，对照组患者进行常规冠心病药物治疗，治疗组在常规治疗基础上加服曲美他嗪6个月，于治疗前后分别测定血清同型半胱氨酸（Hcy）及γ-谷氨酰转肽酶（GGT）含量。结果: 与治疗前相比，在治疗6个月后，所有参与研究的患者血Hcy、GGT水平均有显著下降。与对照组相比，加服曲美他嗪6个月的患者血Hcy、GGT下降更为显著（t=3.147，P＜0.05）。结论:对于稳定型心绞痛患者，在常规治疗基础上加用曲美他嗪，能有效降低血清Hcy及GGT水平，改善患者预后。

关键词: 稳定型心绞痛, 曲美他嗪, 同型半胱氨酸, 谷氨酰转肽酶

Abstract:

AIM: To investigate the effect of trimetazidine on serum-homocysteine and serum-gamma-glutamyl transferase level in the cases of stable angina cordis. METHODS: A total of 80 cases of stable angina cordis patients were included into this study. Conventional drug therapy for coronary heart disease was used for all the patients. In the treatment group, the additional therapy of 6-month trimetazidine was used. Serum-homocysteine and serum-gamma-glutamyl transferase levels were detected before and after treatment. RESULTS:Compared with data collected before treatment, serum-homocysteine and serum-gamma-glutamyl transferase levels in all the patients were significantly decreased after the 6-month therapy. However, more decreases were found in serum-homocysteine and serum-gamma-glutamyl transferase levels in the patients with additional 6-month trimetazidine as compared with the control group.CONCLUSION: Routine treatment plus trimetazidine can effectively reduce the serum-homocysteine and serum-gamma-glutamyl transferase levels and improve patients-outcomes for the patients with stable angina cordis.

Key words: stable angina cordis, trimetazidine, homocysteine, gamma-glutamyl transferase

中图分类号:

R541.4

盛洋，张田杰. 曲美他嗪对稳定型心绞痛患者血清同型半胱氨酸及谷氨酰转肽酶含量的影响[J]. 中国临床药理学与治疗学, 2018, 23(8): 922-926.

SHENG Yang, ZHANG Tianjie. Effects of trimetazidine on serum-homocysteine and serum-gamma-glutamyl transferase level in the cases of stable angina cordis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(8): 922-926.

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曲美他嗪对稳定型心绞痛患者血清同型半胱氨酸及谷氨酰转肽酶含量的影响

Effects of trimetazidine on serum-homocysteine and serum-gamma-glutamyl transferase level in the cases of stable angina cordis

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