促红细胞生成素对急性脊髓损伤患者血清降钙素基因相关肽的影响

doi:10.12092/j.issn.1009-2501.2019.08.014

中国临床药理学与治疗学 ›› 2019, Vol. 24 ›› Issue (8): 933-937.doi: 10.12092/j.issn.1009-2501.2019.08.014

促红细胞生成素对急性脊髓损伤患者血清降钙素基因相关肽的影响

刘亚东¹，卢小伟²，刘志刚³

¹湖北省十堰市国药东风总医院骨外科，²心功能室，十堰 442008，湖北；³武汉市第三医院骨科，武汉 430074，湖北

收稿日期:2019-01-09 修回日期:2019-07-08 出版日期:2019-08-26 发布日期:2019-08-30
通讯作者: 卢小伟，女，本科，主治医师，研究方向：心电图。 Tel：13733593963 E-mail：luxiaowei855@163.com
作者简介:刘亚东，男，本科，副主任医师，研究方向：骨外科。 Tel：13872832015 E-mail：liuyadong62@163.com
基金资助:
2014年十堰市科学技术研究与开发项目（14Y50）

Effects of EPO on serum calcitonin gene-related peptide in patients with acute spinal cord injury

LIU Yadong¹, LU Xiaowei ², LIU Zhigang ³

¹ Department of Bone Surgery, Sinopharm Dongfeng General Hospital, Shiyan 442008, Hubei, China; ² Heart Function Examination Room, Sinopharm Dongfeng General Hospital, Shiyan 442008, Hubei, China; ³ Department of Orthopedics, the Third Hospital of Wuhan, Wuhan 430074, Hubei, China

Received:2019-01-09 Revised:2019-07-08 Online:2019-08-26 Published:2019-08-30

摘要/Abstract

摘要：

目的:探讨促红细胞生成素(erythropoietin,EPO)对急性脊髓损伤患者血清降钙素基因相关肽(calcitonin gene-related peptide,CGRP)的影响。方法:2013年9月到2018年2月选择在本院进行急诊的急性脊髓损伤患者156例，根据治疗方法的不同分为EPO组80例与对照组76例，对照组给予甲强龙冲击治疗，EPO组给予甲强龙联合EPO治疗，两组都连续治疗4周。结果:治疗后两组患者的脊髓神经功能评分都显著高于治疗前(P<0.05)，EPO组也显著高于对照组(P<0.05)。EPO组治疗后的红细胞与血红蛋白值显著高于治疗前(P<0.05)，也高于对照组(P<0.05)，对照组治疗前后红细胞与血红蛋白值对比差异无统计学意义(P>0.05)。EPO组治疗期间的消化道出血、感染、肝肾功能异常等并发症发生率为8.8%，对照组为9.2%(P>0.05)。治疗后两组的血清CGRP值都显著高于治疗前，EPO组也显著高于对照组(P<0.05)。结论:EPO在急性脊髓损伤患者中的应用具有很好的安全性，有利于血清CGPR的释放，改善机体营养状态，提高患者的脊髓神经功能。

关键词: 促红细胞生成素, 急性脊髓损伤, 降钙素基因相关肽, 甲强龙

Abstract:

AIM: To investigate the effects of erythropoietin (EPO) on serum calcitonin gene-related peptide (CGRP) in patients with acute spinal cord injury. METHODS: From September 2013 to February 2018, 156 cases of patients with acute spinal cord injury who were selected for emergency department in our hospital were divided into 80 cases of EPO group and 76 cases of control group according to different treatment methods. The control group was given the treatment of methylprednisolone. The EPO group was given EPO treatment based on the treatment of the control group, and both groups were treated continuously for 4 weeks.RESULTS:The spinal nerve function scores of the two groups were significantly higher than those before treatment (P<0.05), and the EPO group were also significantly higher than the control group (P<0.05). The red blood cell and hemoglobin values in the EPO group were significantly higher than those before treatment (P<0.05), and were also higher than the control group (P<0.05). There was no significant difference in the red blood cell and hemoglobin values before and after treatment in the control group (P>0.05). The incidence of gastrointestinal bleeding, infection, liver and kidney dysfunction during the treatment of EPO group were 8.8%, and that of the control group were 9.2%, there was no significant difference compared between the two groups (P>0.05). The serum CGRP values of the two groups were significantly higher than those before treatment, and the EPO group was also significantly higher than the control group (P<0.05). CONCLUSION:EPO is safe for patients with acute spinal cord injury; it can promote the release of serum CGPR, improves the nutritional status of the body and the spinal nerve function of patients.

Key words: erythropoietin, acute spinal cord injury, calcitonin gene-related peptide, methylprednisolone

中图分类号:

R681.5

刘亚东，卢小伟，刘志刚. 促红细胞生成素对急性脊髓损伤患者血清降钙素基因相关肽的影响[J]. 中国临床药理学与治疗学, 2019, 24(8): 933-937.

LIU Yadong, LU Xiaowei, LIU Zhigang. Effects of EPO on serum calcitonin gene-related peptide in patients with acute spinal cord injury[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(8): 933-937.

参考文献

［1］Bellampalli SS, Ji Y, Moutal A, et al. Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels［J］. Pain, 2019, 160(1): 117-135.
［2］Bigbee AJ, Akhavan M, Havton LA. Plasticity of select primary afferent projections to the dorsal horn after a lumbosacral ventral root avulsion injury and root replantation in rats ［J］. Front Neurol, 2017, 8: 291.
［3］Chung AM. Calcitonin gene-related peptide (CGRP): role in peripheral nerve regeneration ［J］. Rev Neurosci, 2018, 29(4): 369-376.
［4］Yamanaka K, Eldeiry M, Aftab M, et al. Optimized induction of beta common receptor enhances the neuroprotective function of erythropoietin in spinal cord ischemic injury ［J］. J Thorac Cardiovasc Surg, 2018, 155(6): 2505-2516.
［5］杨明朗, 陶陶, 徐坚, 等. 大鼠局灶性脑缺血再灌注后促红细胞生成素蛋白表达的变化［J］. 中华老年医学杂志, 2017, 36(7): 798-801.
［6］Eldahan KC, Rabchevsky AG. Autonomic dysreflexia after spinal cord injury: Systemic pathophysiology and methods of management ［J］. Auton Neurosci, 2018, 209: 59-70.
［7］沈哲, 郭伟壮, 杨欣建. 人脑源性神经营养因子基因修饰BMSCs联合EPO治疗大鼠急性脊髓损伤中的作用及机制［J］. 临床和实验医学杂志, 2018, 17(1): 31-34.
［8］Kalin S, Miller KR, Kalin RE, et al. CNS myeloid cells critically regulate heat hyperalgesia ［J］. J Clin Invest, 2018, 128(7): 2774-2786.
［9］余化龙, 何宁, 刘志刚, 等. 骨髓间充质干细胞联合EPO对急性脊髓损伤大鼠神经运动功能的影响及机制探讨［J］. 山东医药, 2016, 56(18): 37-39.
［10］Liu M, Chen H, Tong M, et al. Effects of ultra-early hyperbaric oxygen therapy on femoral calcitonin gene-related peptide and bone metabolism of rats with complete spinal transection ［J］. Spine (Phila Pa 1976), 2018, 43(16): E919-e926.
［11］Lu R, Flauaus C, Kennel L, et al. KCa3.1 channels modulate the processing of noxious chemical stimuli in mice ［J］. Neuropharmacol, 2017, 125: 386-395.
［12］肖以磊, 周杰, 陈秋兰, 等. rHu-EPO治疗急性脊髓损伤疗效观察(附33例报告)［J］. 山东医药, 2015, 25(9): 46-47.
［13］Wang C, Xu Y, Huang Y, et al. Effects of erythropoietin and methylprednisolone on AQP4 expression in astrocytes ［J］. Mol Med Rep, 2017, 16(5): 5924-5930.
［14］周潇齐, 吴波, 严鑫平, 等. 重组人促红细胞生成素对成年大鼠脊髓中央管膜下神经干细胞增殖能力的影响［J］. 实用医学杂志, 2018, 34(12): 1973-1977.
［15］Samineni VK, Yoon J, Crawford KE, et al. Fully implantable, battery-free wireless optoelectronic devices for spinal optogenetics ［J］. Pain, 2017, 158(11): 2108-2116.
［16］Sliwinski C, Nees TA, Puttagunta R, et al. Sensorimotor activity partially ameliorates pain and reduces nociceptive fiber density in the chronically injured spinal cord ［J］. J Neurotrauma, 2018, 35(18): 2222-2238.
［17］赵亮, 曹阳, 徐莉. 重组人红细胞生成素与β-七叶皂甙钠对大鼠脊髓损伤后功能恢复和神经细胞继发性损伤的影响［J］. 中国免疫学杂志, 2018, 34(4): 589-594.
［18］Vitores AA, Sloley SS, Martinez C, et al. Some autonomic deficits of acute or chronic cervical spinal contusion reversed by interim brainstem stimulation［J］. J Neurotrauma, 2018, 35(3): 560-572.
［19］Foley LS, Fullerton DA, Mares J, et al. Erythropoietin's beta common receptor mediates neuroprotection in spinal cord neurons ［J］. Ann Thorac Surg, 2017, 104(6): 1909-1914.
［20］周利彬, 张乃鹒. 重组人促红细胞生成素联合依达拉奉对脑梗死溶栓后脑缺血再灌注损伤的影响［J］. 医学临床研究, 2017, 34(8): 1622-1624.
［21］Wang X, Ju S, Chen S, et al. Effect of electro-acupuncture on neuroplasticity of spinal cord-transected rats ［J］. Med Sci Monit, 2017, 23: 4241-4251.
［22］朱云鹏, 贾瑞鹏, 周昌成, 等. 红细胞生成素动员肾祖细胞以减缓保留肾单位手术大鼠的缺血再灌注损伤［J］. 中华肾脏病杂志, 2017, 33(10): 775-780.
［23］Zhang S, Liu H, Xu Q, et al. Role of capsaicin sensitive sensory nerves in ischemia reperfusion-induced acute kidney injury in rats ［J］. Biochem Biophys Res Commun, 2018, 506(1): 176-182.
［24］金晓盛, 吴厉锋, 钱小英, 等. 促红细胞生成素后处理对大鼠再灌注损伤肺细胞凋亡的干预及机制［J］. 中国临床药理学与治疗学, 2014, 19(4): 371-376.
［25］Zhu Y, Wu Y, Zhang R. Electro-acupuncture promotes the proliferation of neural stem cells and the survival of neurons by downregulating miR-449a in rat with spinal cord injury［J］. Excli J, 2017, 16: 363-374.

[1]	杨欢, 石玉红, 冉海凤, 陈怡瑾, 徐晓玉. 促红细胞生成素的生理功能及生成来源[J]. 中国临床药理学与治疗学, 2021, 26(4): 434-443.
[2]	全海燕，刘玉环，杨丽，阳芳，秦旭平. CGRP通过激活cAMP/PPARγ/eNOS途径改善血管内皮细胞胰岛素抵抗[J]. 中国临床药理学与治疗学, 2019, 24(6): 615-622.
[3]	张文喜，刘东红，赵蓓，赵佳佳，蔡俏，高未，蔡奔奔. 阿奇霉素联合甲强龙治疗支原体肺炎肺实变患儿的随机对照临床试验[J]. 中国临床药理学与治疗学, 2018, 23(9): 1052-1055.
[4]	李献超，马晓东，郑青秀，刘刚. 桑白利湿汤治疗感染后咳嗽的疗效和对诱导痰中P物质、降钙素基因相关肽水平的影响[J]. 中国临床药理学与治疗学, 2018, 23(11): 1282-1286.
[5]	徐姝娟，吕大伦，陈雷，丁伟，王合丽，张炜，王帅. RHuEPO对大鼠皮肤急性创面愈合过程中血管生成素-1变化的影响[J]. 中国临床药理学与治疗学, 2017, 22(4): 424-427.
[6]	张晓一，于潇华，刘玉环，杨丽，王珍，阳芳，秦旭平，曾泗宇. ERK1/2和p38MAPK在介导CGRP和Ang II诱导血管平滑肌细胞Nox1表达中的作用[J]. 中国临床药理学与治疗学, 2017, 22(1): 13-19.
[7]	何艳鲁卫华秦雪梅金孝岠. 脓毒症大鼠肠道瞬时感受器电位香草酸受体1及降钙素基因相关肽的表达及作用[J]. 中国临床药理学与治疗学, 2016, 21(1): 38-41.
[8]	金晓盛, 吴厉锋, 钱小英, 邵美琴, 王万铁. 促红细胞生成素后处理对大鼠再灌注损伤肺细胞凋亡的干预及机制[J]. 中国临床药理学与治疗学, 2014, 19(4): 371-376.
[9]	顾兵, 王烁宇, 李华南, 王俊, 张水印. 促红细胞生成素早期治疗大鼠脊髓挫伤的形态学研究[J]. 中国临床药理学与治疗学, 2013, 18(2): 147-155.
[10]	邓水秀, 曾泗宇, 任俊芳, 郑元斌, 廖端芳, 秦旭平. 降钙素基因相关肽对大鼠血管平滑肌细胞CDK2和Cyclin E的影响[J]. 中国临床药理学与治疗学, 2011, 16(3): 249-253.
[11]	叶夷露, 张琦, 季华, 张建亭, 黄春燕, 俞月萍, 饶艳. 重组人促红细胞生成素鼻腔给药对大鼠慢性脑缺血的保护作用[J]. 中国临床药理学与治疗学, 2010, 15(9): 997-1001.
[12]	金小红, 陈存国, 李凤仙, 李绍波, 陈丽丽, 陈保国, 童夏生. 中重度哮喘急性发作患儿血中EAN-78 的表达及甲基强的松龙对其表达的影响[J]. 中国临床药理学与治疗学, 2009, 14(5): 564-566.
[13]	秦旭平, 谌赟, 秦又发, 田海宏, 孙飞. 氯沙坦和哌唑嗪调节早期高血压大鼠体内降钙素基因相关肽反应的差异[J]. 中国临床药理学与治疗学, 2009, 14(1): 42-47.
[14]	俞月萍, 叶夷露. 促红细胞生成素对脑缺血的保护作用研究进展[J]. 中国临床药理学与治疗学, 2007, 12(6): 609-613.
[15]	朱良红, 程光华, 张新路. 手术创伤与血浆内皮素和降钙素基因相关肽水平相关性的临床研究[J]. 中国临床药理学与治疗学, 2006, 11(12): 1420-1422.

促红细胞生成素对急性脊髓损伤患者血清降钙素基因相关肽的影响

Effects of EPO on serum calcitonin gene-related peptide in patients with acute spinal cord injury

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价