剖宫产时蛛网膜下隙0.75%罗哌卡因麻醉的ED50

中国临床药理学与治疗学 ›› 2008, Vol. 13 ›› Issue (8): 905-908.

剖宫产时蛛网膜下隙0.75%罗哌卡因麻醉的ED₅₀

沈晓署, 甘果, 袁力勇

宁波市妇女儿童医院麻醉科, 宁波315012, 浙江

收稿日期:2008-06-02 修回日期:2008-07-23 出版日期:2008-08-26 发布日期:2020-10-12
通讯作者: 袁力勇, 男, 硕士, 副主任医师, 主要研究方向:麻醉药理学。Tel:13967804761　E-mail:ylysgl@hotmaIl.com
作者简介:沈晓署, 女, 大专, 主治医师, 主要研究方向:临床麻醉。Tel:0574-87083324
基金资助:
宁波市医学科技项目(2005538, 2006009, 2007014)

Determination of the ED₅₀ of spinal anesthesia 0.75% ropivacaine for cesarean section

SHEN Xiao-shu, GAN Guo, YUAN Li-yong

Department of Anesthesiology, Ningbo Women & Children's Hospital, Ningbo 315012, Zhejiang, China

Received:2008-06-02 Revised:2008-07-23 Online:2008-08-26 Published:2020-10-12

摘要/Abstract

摘要： 目的:确定剖宫产时蛛网膜下隙0.75%罗哌卡因(ropivacaine, Rop)麻醉的半数有效剂量(ED₅₀)。方法:32名ASA Ⅰ～Ⅱ 、择期在蛛网膜下隙-硬膜外隙联合麻醉(combined spinal-epidural anesthesia,CSEA)下剖宫产产妇参加试验。第一位产妇0.75% Rop 剂量为12.8 Mg, 以相邻剂量的98.4%为剂量的变化幅度。感觉、运动神经阻滞分别以针刺法及改良Bromage 法测定。麻醉有效的指标为:蛛网膜下隙给药后10 min 内感觉平面阻滞达到T₇、Bromage 达3分、切皮不痛、肌松满意。计算剖宫产时蛛网膜下隙0.75% Rop 麻醉的ED₅₀ 及其95%可信区间(CI)。结果:32名产妇中有5例麻醉效果可疑, 剔除出本研究。根据其余27名产妇序贯试验得出剖宫产时蛛网膜下隙0.75% Rop 麻醉的ED₅₀ 为11.97mg, ED₅₀ 的95%CI为11.75～12.19 mg 。结论:L3～4间隙CSEA 下剖宫产时, 蛛网膜下隙0.75%罗哌卡因麻醉的ED₅₀ 为11.97mg 。

关键词: 剖宫产, 蛛网膜下隙-硬膜外隙联合麻醉, 罗哌卡因, 半数有效剂量

Abstract: AIM:To determine the median effective dose (ED₅₀)of spinal anesthesia 0.75% ropivacaine for cesarean section.METHODS:Thirty-two ASA Ⅰ-Ⅱ parturients undergoing elective cesarean section delivery with use of combined spinal-epidural anesthesia were enrolled in this study.The initial dose of was 12.8 Mg of 0.75%ropivacaine, and the dosing intervals were 98.4% of the preceding dosage.Doses for subsequent parturients were determined by the response of the previous parturient.Successful anesthesia was defined as a loss of sensation to an acupuncture stimulus at the T₇ level, full motor blockade within 10 minutes after administration of the local anesthetic, analgesia of incision and the satisfaction of skelaxin evaluated by one operator.ED₅₀ and its 95% confidence interval (CI)was determined with use of Dixon method.RESULTS:Five parturients were rejected out the study because of doubtful anesthsia.According to the rest twenty-seven parturients'data, the ED₅₀ of intrathecal 0.75% ropivacaine was 11.97mg (95% confidence interval [CI], 11.75-12.19 mg).CONCLUSION:The ED₅₀ of spinal 0.75% ropivacaine for cesarean delivery under the conditions of this study were 11.97mg.

Key words: cesarean section, combined spinalepidural anesthesia, ropivacaine, median effective dose

中图分类号:

R614

沈晓署, 甘果, 袁力勇. 剖宫产时蛛网膜下隙0.75%罗哌卡因麻醉的ED₅₀[J]. 中国临床药理学与治疗学, 2008, 13(8): 905-908.

SHEN Xiao-shu, GAN Guo, YUAN Li-yong. Determination of the ED₅₀ of spinal anesthesia 0.75% ropivacaine for cesarean section[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(8): 905-908.

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剖宫产时蛛网膜下隙0.75%罗哌卡因麻醉的ED₅₀

Determination of the ED₅₀ of spinal anesthesia 0.75% ropivacaine for cesarean section

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