内质网应激与动脉粥样硬化

中国临床药理学与治疗学 ›› 2008, Vol. 13 ›› Issue (8): 947-951.

内质网应激与动脉粥样硬化

方希, 薛丹婷, 方立, 张陆勇

中国药科大学新药筛选中心, 南京210038, 江苏

收稿日期:2008-04-23 修回日期:2008-06-19 出版日期:2008-08-26 发布日期:2020-10-12
通讯作者: 张陆勇, 男, 教授, 博士生导师, 研究方向:分子毒理学和药物筛选。Tel:025-83271500　E-mail:drugscreen@126.com
作者简介:方希, 女, 本科, 研究方向:分子药理学。Tel:13951035248　E-mail:fangxi1985@163.com
基金资助:
国家基础科学人才培养基金(J0630858)

Endoplasmic reticulum stress and atherosclerosis

FANG Xi, XUE Dan-ting, FANG Li, ZHANG Lu-yong

New Drug Screening Center, China Pharmaceutical University, Nanjing 210038, Jiangsu, China

Received:2008-04-23 Revised:2008-06-19 Online:2008-08-26 Published:2020-10-12

摘要/Abstract

摘要： 在动脉粥样硬化的病理机制的研究中, 内质网应激的作用越来越受到关注。本文拟就内质网应激与动脉粥样硬化的关系作一综述。内质网应激通过在炎症反应、脂质代谢异常、细胞凋亡中起的潜在作用, 可能参与动脉粥样硬化发生和发展的机理。同时, 血浆高半胱氨酸、高血糖等独立危险因子与内质网应激过程相互作用而诱导动脉粥样硬化。

关键词: 动脉粥样硬化, 内质网应激, 炎症, 高血浆同型半胱氨酸, 糖尿病

Abstract: Endoplasmic reticulum stress has drawn much attention recently because of its potential roles in the pathomechanism of atherosclerosis.This review focused on the role of endoplasmic reticulum stress played in the initiation and development of atherosclerosis involving inflammation production, lipid metabolism dysfunction and cell apoptosis.Further more, some independent risk factors, such as hyperhomocysteinemia and hyperglycemia also induce the atherosclerosis via endoplasmic reticulum stress.

Key words: atherosclerosis, endoplasmic reticulum stress, inflammation, hyperhomocysteinemia, hyperglycaemia

中图分类号:

R541.4

方希, 薛丹婷, 方立, 张陆勇. 内质网应激与动脉粥样硬化[J]. 中国临床药理学与治疗学, 2008, 13(8): 947-951.

FANG Xi, XUE Dan-ting, FANG Li, ZHANG Lu-yong. Endoplasmic reticulum stress and atherosclerosis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(8): 947-951.

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