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中国临床药理学与治疗学 ›› 2008, Vol. 13 ›› Issue (11): 1277-1281.

• 定量药理学 • 上一篇    下一篇

豆腐果苷衍生物W0620实验性抗抑郁作用量效关系研究

童九翠, 孙瑞元, 江思艳, 杨斌, 芮家亮, 李娟, 谢海棠   

  1. 皖南医学院弋矶山医院安徽省药物临床评价中心, 芜湖 241001, 安徽
  • 收稿日期:2008-10-11 修回日期:2008-11-30 出版日期:2008-11-26 发布日期:2020-10-14
  • 通讯作者: 谢海棠,女, 副研究员, 硕士生导师, 研究方向:中药药理和临床定量药理学。Tel:0553-5738350 E-mail: xiehaitang@sina.com
  • 作者简介:童九翠, 女, 医学硕士, 助理研究员, 研究方向:中药药理和临床定量药理学。Tel:0553-5738350 E-mail: tongjc3978@126.com
  • 基金资助:
    国家中医药管理局基金资助项目(200707008)

Experimental study for antidepressant effects on the dose-effect relationship of Helicid derivate W0620

TONG Jiu-cui, SUN Rui-yuan, JIANG Si-yan, YANG Bin, RUI Jia-liang, LI Juan, XIE Hai-tang   

  1. Anhui Provincial Center for Drug Clinical Evaluation, Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui China
  • Received:2008-10-11 Revised:2008-11-30 Online:2008-11-26 Published:2020-10-14

摘要: 目的: 观察豆腐果苷衍生物W0620 对悬尾小鼠不动时间的影响并初步探讨其剂量与效应关系。方法: 应用行为绝望抑郁模型———小鼠悬尾实验研究不同剂量W0620 对实验小鼠不动时间的影响, 同时应用小鼠自主活动实验观察不同剂量W0620 对中枢兴奋作用的影响。结果: 5.91 、17.73 、53.20 、159.60 mg /kg 4 个剂量组对小鼠自主活动均无影响(P >0.05), 17.73 、53.20 、159.60 mg /kg 3 个剂量组能明显缩短悬尾实验中小鼠的不动时间(P <0.01) 。W0620 的对数剂量与抗抑郁药效呈现S 型量效关系, 药效动力学参数如下:Emax 80.79 s 、Ebase 12.13 s 、K 9.16 mg /kg 、H 3.38 、ED50 9.16 mg /kg 、E50 46.46 s 、ED80 13.81 mg /kg 、E80 67.05 s 、ED90 17.56 mg /kg 、E90 73.92 s 。结论: W0620 有明显抗抑郁作用, 其量效关系符合S 型曲线, 无明显中枢抑制作用。

关键词: 豆腐果苷, W0620, 抗抑郁药, 量效关系, 小鼠悬尾实验, 自主活动

Abstract: AIM: To investigate the dose-effect relationship of Helicid derivate W0620 for immobility time using the tail suspension test in mice. METHODS: Antidepressant effects of different dosage of W0620 were studied on the behavioral despair animal model-tail suspension test in mice, and the stimulative effects on the central nervous system (CNS) were observed by the autonomic activity test in mice. RESULTS: Four dose groups of W0620(5.91, 17.73, 53.20, 159.60 mg /kg) had no effects on autonomic activity in mice (P >0.05), and three dose groups of W0620(17.73, 53.20, 159.60 mg /kg) could significantly shorten the mice immobility time (P <0.01) compared with that of the control group. A sigmoid curvilinear relationship was shown between the logarithmic doses of W0620 and the antidepressant effects, the pharmacodynamic parameters were as follow: Emax 80.79 s, Ebase 12.13 s, K 9.16 mg /kg, H 3.38, ED50 9.16 mg /kg, E50 46.46 s, ED80 13.81 mg /kg, E80 67.05 s, ED90 17.56 mg /kg, E90 73.92 s. CONCLUSION: W0620 has an obviously antidepressant effect whereas it has no inhibition action on CNS. There is a sigmoid curvilinear relationship between the logarithmic doses and the antidepressant effects.

Key words: Helicid, W0620, antidepressive agents, dose-effect relationship, tail suspension test in mice, automomic activity

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