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中国临床药理学与治疗学 ›› 2008, Vol. 13 ›› Issue (11): 1291-1294.

• 药物治疗学 • 上一篇    下一篇

奥拉西坦与盐酸多奈哌齐治疗阿尔茨海默病的随机双盲对照研究

倪建良, 王水洪, 杨华, 陈松, 魏利娟   

  1. 浙江省立同德医院老年一科, 杭州 310012, 浙江
  • 收稿日期:2008-10-11 修回日期:2008-10-17 出版日期:2008-11-26 发布日期:2020-10-14
  • 作者简介:倪建良, 男, 本科, 副主任医师, 研究方向:老年痴呆。E-mail: 6368356@qq.com

A randomized double-blind control study on oxiracetam and donepezil in treating Alzheimer disease

NI Jian-liang, WANG Shui-hong, YANG Hua, CHEN Song, WEI Li-juan   

  1. First Department of Geriatrics, Zhejiang Provincial Tongde Hospital, Hangzhou 310012, Zhejiang, China
  • Received:2008-10-11 Revised:2008-10-17 Online:2008-11-26 Published:2020-10-14

摘要: 目的: 比较奥拉西坦与盐酸多奈哌齐治疗轻、中度MMSE 评分(11 ~ 24 分) 阿尔茨海默病(Alzheimer disease,AD) 的疗效和安全性。方法: 68例患者随机分为奥拉西坦组(34 例, 采用奥拉西坦口服) 、盐酸多奈哌齐组(34 例, 采用盐酸多奈哌齐口服), 疗效评价使用MMSE 和Blessed-Roth行为量表, 在治疗前和治疗后3 个月进行检测。结果: 治疗前后比较两组各指标除日常生活能力外均有改善, 差异有统计学意义(P <0.01) 。两组等效 非劣性检验显示,MMSE 评分两组等效(P<0.05), Blessed-Roth 评分奥拉西坦组劣于盐酸多奈哌齐组(P >0.05) 。结论: 奥拉西坦对轻、中度AD 的疗效和安全性与盐酸多奈哌齐相仿。

关键词: 奥拉西坦, 盐酸多奈哌齐, 阿尔茨海默病

Abstract: AIM: To compare the efficacy and safety of oxiracetam and donepezil in treating Alzheimer disease with mild and moderate MMSE scores. METHODS: 68 patients were randomly divided into oxiracetam group(p.o., n =34) and donepezil group (p.o., n =34). The MMSE and Blessed-Roth measuring scales were used to evaluate the curative effects before treatment and three months after treatment. RESULTS: There were significant differences between the indexes expect for activities of daily living before and after treatment in two groups (P <0.01). The isoeffect or unpessimum test showed the MMSE scores in the two groups were isoeffective, the Blessed-Roth scores in oxiracetam group were inferior to those in donepezil group(P >0.05). CONCLUSION: The curative effect and safety of oxiracetam and donepezil in treating mild and moderate Alzheimer disease are similar.

Key words: oxiracetam, donepezil, Alzheimer disease

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