靶向诱导DNA 甲基化与肿瘤治疗研究进展

中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (3): 241-244.

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靶向诱导DNA 甲基化与肿瘤治疗研究进展

马爱妞, 王永祥, 周向军

上海交通大学药学院分子与系统药理学实验室, 上海200240

收稿日期:2009-03-16 修回日期:2009-03-16 发布日期:2020-10-27
作者简介:马爱妞, 女, 在职博士研究生, 助理研究员, 研究方向:表观遗传药理学。Tel:021-34204772 E-mai l:anma @sjtu.edu.cn

Advances in targeted induction of DNA methylation and cancer therapy

MA Ai-niu, WANG Yong-xiang, ZHOU Xiang-jun

School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China

Received:2009-03-16 Revised:2009-03-16 Published:2020-10-27

摘要/Abstract

摘要： DNA 甲基化是表观遗传调控的重要方式之一, 它能在转录水平上抑制相关基因的表达, 从而引起基因沉默。近年来的研究表明, DNA 的甲基化不仅在生物体内自然发生, 而且可通过特异的RNA 、DNA 等靶向诱导产生。肿瘤的细胞中存在癌基因的异常低甲基化, 而且这种异常被认为是肿瘤的发病机制之一。因此, 通过靶向诱导癌基因甲基化来抑制癌基因的表达、抑制肿瘤生长的方法, 为肿瘤治疗提供了一种新的思路。本文就靶向诱导DNA 甲基化与肿瘤治疗的临床前研究进展作一简述。

关键词: DNA 甲基化, 基因沉默, 表观遗传调控, 肿瘤治疗.

Abstract: DNA methylation is one of the important events in epigenetic regulation.It inhibits gene expression in the transcription level resulting in gene silencing.Recent studies revealed that DNA methylation not only occurs naturally in organism, but also targeting induced by special RNA DNA.Oncogenesis exist abnormally low methylation in tumor cells, which is considered to be one of the pathogeneses of tumors.Thus inhibition of the expression of oncogenesis and the growth of tumor by targeted induction of DNA methylation provides a new way for cancer therapy.This review summarizes the effects of targeted induction of DNA methylation on cancer therapy in preclinical studies.

Key words: DNA methylation, gene silencing, epigenetic regulation, cancer therapy

中图分类号:

R73-3

马爱妞, 王永祥, 周向军. 靶向诱导DNA 甲基化与肿瘤治疗研究进展[J]. 中国临床药理学与治疗学, 2009, 14(3): 241-244.

MA Ai-niu, WANG Yong-xiang, ZHOU Xiang-jun. Advances in targeted induction of DNA methylation and cancer therapy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(3): 241-244.

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靶向诱导DNA 甲基化与肿瘤治疗研究进展

Advances in targeted induction of DNA methylation and cancer therapy

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