人粒细胞无形体病的诊治进展

中国临床药理学与治疗学 ›› 2007, Vol. 12 ›› Issue (9): 980-983.

人粒细胞无形体病的诊治进展

喻艳林¹, 杨进孙¹, 芮景²

¹皖南医学院附属弋矶山医院感染性疾病科, ²普外科, 芜湖241001, 安徽

收稿日期:2007-08-29 修回日期:2007-09-30 出版日期:2007-09-26 发布日期:2020-10-30
通讯作者: 芮景, 男, 硕士生导师, 研究方向:蛇毒抗肿瘤。E-mail:ruijing1956@sina.com
作者简介:喻艳林, 女, 主任医师, 副教授, 研究方向:感染性疾病、急救医学。Tel:13955368398 E-mail:yuyanlin1104@sohu.com

Advances in diagnosis and treatment on human granulocytic anaplasmosis

YU Yan-lin¹, YANG Jin-sun¹, RUI Jing²

¹Department of Infectious diseases, ²Department of General Surgery, Affiliated Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui, China

Received:2007-08-29 Revised:2007-09-30 Online:2007-09-26 Published:2020-10-30

摘要/Abstract

摘要： 人粒细胞无形体病是由人嗜粒细胞无形体引起的一种经蜱传播的新发的自然疫源性疾病。该病主要临床表现为发热、消化道及血液系统症状等, 少数严重患者可因多脏器功能衰竭而死亡。近年来,在美国、欧洲、非洲等地均有相关病例报道, 我国也有病例发现。该病日益受到人们的关注和重视, 本文就人粒细胞无形体病的诊断与治疗研究的进展作一综述。

关键词: 埃立克体, 人嗜粒细胞无形体, 诊断, 治疗

Abstract: Human granulocytic anaplasmosis (HGA) is an emerging tick-borne natural focal disease caused by Anaplasma phagocytophilum.Its clinical characters mainly include symptoms of febrile illness, digestive tract and blood system.A few severe patients die with multiple system organ failure.The cases of HGA were recently reported in America, Europe and Africa, and also found in our country.The disease has attracted more attention.The advances of diagnosis and treatments on HGA is reviewed in this article.

Key words: Ehrlichia, human granulocytic anaplasmosis, diagnosis, treatment

中图分类号:

R376

喻艳林, 杨进孙, 芮景. 人粒细胞无形体病的诊治进展[J]. 中国临床药理学与治疗学, 2007, 12(9): 980-983.

YU Yan-lin, YANG Jin-sun, RUI Jing. Advances in diagnosis and treatment on human granulocytic anaplasmosis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(9): 980-983.

参考文献

1 Dumler JS.Anaplasma and Ehrlichia infenction [J].Ann N Y Acad Sci, 2005;1063:361-373.
2 Strle E.Human granulocytic ehrlichiosis in Europe [J].Int J Med Microbiol, 2004;37:27-35.
3 Dumler JS, Barat NC, Barat CE, et al.Human granulocytic anaplasmosis and macrophage activation [J].Clin Infect Dis, 2007;45:199-204.
4 高东旗, 曹务春, 张习坦, 等.大兴安岭地区人群埃立克体感染的调查 [J].中华流行病学, 2001;22 :137-141.
5 Grzeszczuk A.Anaplasma phagocytophilum in Ixodes ricinus ticks and human granulocytic anaplasmosis seroprevalence among forestry rangers in Bia ? y stok region [J].Adv Med Sci, 2006; 51:283-286.
6 Demma LJ, Holman RC, Mcquiston JH, et al.Epidemiology of human ehrlichiosis and anaplasmosis in the United States, 2001-2002 [J].Am J Trop Med Hyg, 2005;73 :400-409.
7 贺联印, 许炽瞟.热带病学 [M].第2 版.北京:人民卫生出版社, 2004:371-381.
8 Dhand A, Nadelman RB, Aguero-Rosenfeld M, et al.Human granulocytic anaplasmosis during pregnancy :case series and literature review [J].Clin Infect Dis, 2007;45 :589-593.
9 Zhang JZ, Guo H, Winslow GM, et al.Expression of members of the 28-kilodalton major outer membrane protein family of ehrlichia chaffeensis during persistent infection [J].Infect Immun, 2004;72:4336-4343.
10 Choi KS, Dumler JS.A mitogenic component in polar lipid-enriched A.phagocytophilum membranes [J].Clin Vaccine Immunol, 2007;(In Print)
11 Bitsaktsis C, Huntington J, Winslow G.Production of IFNgamma by CD4 T cells is essential for resolving Ehrlichia infection [J].J Immunol, 2004;172 :6894-6901.
12 Choi KS, Webb T, Oelke M, et al.Differential innate immune cell activation and proinflammatory response in Anaplasma phagocytophilum infection [J].Infect Immun, 2007;75 :3124-3130.
13 Dumler JS, Madigan JE, Pusterla N, et al.Ehrlichioses in humans: epidemiology, clinical presentation, diagnosis, and treatment [J].Clin Infect Dis, 2007;45:S45-51.
14 Walker DH.Ehrlichia under our noses and no one notices [J]. Arch Virol, 2005;19:147-156.
15 Chapman AS, Bakken JS, Folk SM, et al.Diagnosis and management of tickborne rickettsial diseases :Rocky Mountain spotted fever, ehrlichioses, and anaplasmosis-United States [J]. MMWR Recomm Rep, 2006;55:1-27.
16 Alberti A, Sparagano OA.Molecular diagnosis of granulocytic anaplasmosis and infectious cyclic thrombocytopenia by PCRRFLP [J].Ann N Y Acad Sci, 2006;1081 :371-378.
17 Martinez D, Vachiery N, Stachruski F, et al.Nested PCR for detection and genotyping of Ehrlichia ruminantium :use in genetic diversity analysis [J].Ann N Y Acad Sci, 2004;1026: 106-113.
18 Blas-Machado U, de la Fuente J, Blouin EF, et al.Experimental infection of C³H HeJ mice with the NY18 isolate of Anaplasma phagocytophilum [J].Vet Pathol, 2007;44:64-73.
19 Gardner SL, Holman RC, Krebs JW, et al.National surveillance for the human ehrlichioses in the United States, 1997-2001, and proposed methods for evaluation of data quality [J]. Ann N Y Acad Sci, 2003;990 :80-89.
20 Brouqui P, Bacellar F, Baranton G, et al.Guidelines for the diagnosis of tick-borne bacterial diseases in Europe [J].Clin Microbiol Infect, 2004;10:1108-1132.
21 Bakken JS, Dumler JS.Clinical diagnosis and treatment of human granulocytotropic anaplasmosis [J].Ann N Y Acad Sci, 2006;1078:236-247.
22 Branger S, Rolain JM, Raoult D.Evaluation of antibiotic susceptibilities of Ehrlichia canis, Ehrlichia chaffeensis and Anaplasma phagocytophilum by real-time PCR [J].Antimicrob Agents Chemother, 2004;48:4822-4828.

[1]	何李华, 朱秀之, 江一舟. 三阴性乳腺癌免疫治疗研究进展[J]. 中国临床药理学与治疗学, 2023, 28(8): 842-853.
[2]	张胡云龙, 朱秀之, 金希, 邵志敏. 腔面型乳腺癌内分泌治疗耐药的机制与治疗进展[J]. 中国临床药理学与治疗学, 2023, 28(8): 854-865.
[3]	付晓玉, 孔德光, 李娟娟. 三阳性乳腺癌的治疗进展[J]. 中国临床药理学与治疗学, 2023, 28(8): 866-875.
[4]	罗师萍, 张捷, 俞育帅, 宋传贵. HER2阳性乳腺癌的靶向治疗进展[J]. 中国临床药理学与治疗学, 2023, 28(8): 876-886.
[5]	向奕玫, 张宁宁, 黄雨昕, 曾晓华. HER2阳性乳腺癌疗效相关生物标志物研究进展[J]. 中国临床药理学与治疗学, 2023, 28(8): 887-897.
[6]	侯琼, 刘飞, 陈传荣. 免疫治疗联合抗血管生成药物+化疗在驱动基因阴性晚期非小细胞肺癌中的应用[J]. 中国临床药理学与治疗学, 2023, 28(7): 775-779.
[7]	王安婧, 王亚亚, 梁轩, 闫雅婕, 苏静, 李彩东. 基于PPAR治疗胆汁淤积性肝病的机制与药物研究进展[J]. 中国临床药理学与治疗学, 2023, 28(7): 796-808.
[8]	李青华, 赵艳, 赵海港, 高朋飞, 徐炳欣. ABCB1 G2677T 基因多态性检测在缺血性脑卒中患者应用阿托伐他汀降脂治疗中的价值[J]. 中国临床药理学与治疗学, 2023, 28(6): 633-640.
[9]	王娟, 刘维英, 叶育才, 付文丽, 张莎, 李乐萍. 去甲肾上腺素再摄取抑制剂联合抗毒蕈碱剂治疗阻塞性睡眠呼吸暂停的研究进展[J]. 中国临床药理学与治疗学, 2023, 28(6): 714-720.
[10]	陈满新, 张丙雨, 戴敏. 冠状动脉内靶向应用重组人尿激酶原联合经皮冠状动脉成形术治疗高负荷血栓急性心肌梗死临床疗效[J]. 中国临床药理学与治疗学, 2023, 28(5): 544-549.
[11]	张莉, 蔺兴遥, 尚芸, 王强. 冻伤的病理机制及治疗研究进展[J]. 中国临床药理学与治疗学, 2023, 28(3): 347-354.
[12]	俞亚红, 宋昱. 左心室辅助装置植入患者的药物治疗[J]. 中国临床药理学与治疗学, 2023, 28(2): 198-204.
[13]	王丹, 鄢晓丽, 张渊. 幽门螺杆菌感染影响胃癌免疫治疗的研究进展[J]. 中国临床药理学与治疗学, 2023, 28(2): 228-234.
[14]	吴莉莉, 梁至, 黄思咏, 王妍. 肾功能亢进对感染性心内膜炎患者万古霉素药动学的影响及有效性与安全性研究[J]. 中国临床药理学与治疗学, 2023, 28(10): 1139-1145.
[15]	党洋斌, 梁宇欣, 王天成. 进行性肌阵挛癫痫相关治疗的研究进展[J]. 中国临床药理学与治疗学, 2023, 28(10): 1184-1194.